scholarly journals Investigation of the mutagenic effects of aluminium trioxide implants on embrions in experimental animals

2002 ◽  
Vol 49 (1-2) ◽  
pp. 34-39
Author(s):  
Obrad Zelic ◽  
Vladimir Arsenijevic ◽  
Dragoslav Djukanovic ◽  
Bozidar Dimitrijevic ◽  
Jasmina Markov ◽  
...  
Keyword(s):  
Alveolar Bone ◽  
Mutagenic Effect ◽  
Negative Control ◽  
Control Group ◽  
Male Mice ◽  
Female Mice ◽  
Periodontal Tissues ◽  
Group I ◽  
Mutagenic Effects ◽  
Fertile Male

Several diseases as well as trauma can affect the composition and integrity of periodontal tissues loading eventually to the destruction of connective tissue matrix and cells, loss of attachment and resorption of alveolar bone often followed by tooth loss. Replacement of the missing tooth could then be provided by endosseous dental implants healing in a form of osseo -or fibrosseal integration to the alveolar bone. Aluminium oxide ceramics, a form, of endosseous implant, allows osseointegration type of healing and has demonstrated excellent biocompatibility. However, potential aluminium toxicity has been implicated in the pathogenesis of a number of clinical disorders and for this reason we examined the reproductive and mutagenic effect of aluminium trioxide ceramic implant in experimental mice. 720 female and 45 fertile male BALB-cAn NCR mice were included in the study. 3 experimental groups of fertile male mice (15 for each group) were treated with an intraperitoneal injection of aluminium trioxide (I g/kg of body weight, group I), with ethyl-methane-sulphonate as a positive control (200 mg/kg, group II) and with Tween-80 (10 ing/kg as negative control, Group III). Each of the labeled male mice fertilized previously uncoupled female mice during 8 weeks (a pair per week) to facilitate appropriate pre-and post-meiotic conditions of spermatogenesis to occur. Female mice were sacrificed with cervical dislocation at day 13 after fertilization. Immediately upon sacrifice the uterus was removed and the number of alive and healthy, or alive but mutated and/or dead embryos was computed to determine the dominant lethal of mutagenic effects. Animals treated with aluminium trioxide demonstrated similar effects on the reproductive and mutagenic capacity as the negative control, whereas the animals treated as positive controls exhibited significantly reduced reproductive and mutagenic capacity. Collectively, we concluded that aluminium trioxide has a very low rate of embryonal mortality and mutagenicity in mice. This finding is in general agreement with the biocompatibility of aluminium trioxide (Aldovit) as an implant material.

scholarly journals UJI EFEK TONIKUM EKSTRAK ETANOL DAUN SAMBILOTO (Andrographis paniculata, Nees.) TERHADAP MENCIT JANTAN (Mus musculus L.) GALUR SWISS

1970 ◽  
Vol 6 (02) ◽  
pp. 17-22 ◽  
Author(s):  
Susi Endrawati ◽  
Feni Indriyani
Keyword(s):  
Mus Musculus ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Probit Analysis ◽  
Control Group ◽  
Test Substance ◽  
Male Mice ◽  
Group I ◽  
Body Strength

The tonic is a substance that can improve our body strength. It can recover the staff our body shortly. It can also make our body stronger and can stimulates our appetite. Knowing the most effective tonic effect dose variation among ethanol extract of bitter leaf on male mice (Mus musculus L.) Swiss Strain. This study is an experimental research design with True experimental design approach Posttest Pretest with control group. The ethanol extract of bitter leaf is made with bitter leaf quote using ethanol 96% with maceration method. The provision of treatment in test animals distinguished on several variations of dosage. In preparation extracts there are 5 groups, namely: group I, II, III, IV, V treated positive control caffeine 13 mg / kg, cooking oil as a negative control, the ethanol extract at a dose of 50 mg / kg, 100 mg / kg, 200 mg / kg. Data obtained tonic effect of added time the mice's ability to defend itself when direnangkan. Data were analyzed by ANOVA using SPSS 18.0 for windows followed by a test post hoc test and ED50 probit analysis to determine the most effective dose as a tonic. Ethanol extract of bitter leaf at a dose of 50 mg / kg have a tonic effect of 9.2 minutes, a dose of 100 mg / kg have a tonic effect of 13.4 minutes, and a dose of 200 mg / kg have a tonic effect 23 minutes. Results yield of ethanol extract of bitter leaf maceration 7.8% b/b. The ethanol extract of bitter leaf tested in test animals male mice (Mus muculus L.) at all doses provide a tonic effect, and the effect will increase along with increasing doses of test substance preparation.

Activity of Ethanol Extract of Tinospora crispa (L.) Hook in Increasing Swimming Endurance on Male Mice Using Natatory Exhaustion Method

2021 ◽  
pp. 5439-5442
Author(s):  
Aninditha Rachmah Ramadhiani ◽  
Galih Pratiwi ◽  
Eka Fitriani ◽  
Kurniawaty Kurniawaty
Keyword(s):  
Body Weight ◽  
Side Effects ◽  
Ethanol Extract ◽  
Negative Control ◽  
Control Group ◽  
Male Mice ◽  
Control Group Design ◽  
Group I ◽  
Swimming Endurance ◽  
Exhaustion Method

The use of stamina-enhancing drugs is now increasingly widespread. Continuous use of stamina medication can cause side effects such as insomnia, feeling nervous and emotional. Therefore, it is necessary to look for effective drugs, relatively low side effects, and relatively cheap prices. One of them is to use natural materials such as Tinospora crispa (L.) Hook stems. This study is to find out the tonic effect extract ethanol of Tinospora crispa stem against male mice with the Natatory Exhaustion Method. This research is an experimental study with a posttest matched control group design. Tonic effect test experiments were conducted using the Natatory Exhaustion Method. Test animals as many as 25 mice were divided into 5 groups, group I, II, III has given Tinospora crispa stem ethanol extract (100,200 and 400 mg/kg body weight). Group IV was given 100 mg/kg body weight of caffeine (positive control) and group V given 25 mL/kg body weight of Carboxymethylcellulose sodium 0.5 % (negative control). Test reserved per oral for 14 days. Test showing that administration 100, 200, and 400 mg/kg body weight of Tinospora crispa stem ethanol extract gave tonic effect on male mice. Mann-Whitney tests showed that the administration of Tinospora crispa stem ethanol extract doses of 100, 200, and 400 mg/kg body weight gave a tonic effect on male mice with significant value (p<0.05) compared to the administration of Carboxymethylcellulose sodium 0.5%, administration of 400 mg/kg body weight extract ethanol of Tinospora crispa stem has a tonic effect on mice which differs noticeably with the administration of caffeine 100 mg/kg body weight with significant value (p<0.05). The present investigation revealed that Tinospora crispa stem ethanol extract shows tonic effect by increasing swimming endurance on male mice.

Efek Ekstrak Etanol Kulit Petai (Parkia speciosa Hassk) Terhadap Penurunan Kadar Glukosa Darah Mencit Jantan

2018 ◽  
Vol 3 (1) ◽  
pp. 1
Author(s):  
Verawaty Verawaty ◽  
Dhea Claudia Novel
Keyword(s):  
Blood Glucose ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Male Mice ◽  
Glucose Levels ◽  
The Third ◽  
Blood Glucose Levels

<p>Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak etanol kulit petai (Parkia speciosa Hassk) terhadap penurunan kadar glukosa darah mencit jantan yang diinduksi aloksan. Hewan percobaan dibagi atas 5 kelompok diantaranya kelompok kontrol negatif, kelompok kontrol positif,dosis I (280 mg/kgBB mencit), dosis II (560 mg/kg BB mencit), dosis III (840 mg/kg BB mencit). Penelitian dilakukan selama 21 hari. Persentase penurunan kadar glukosa darah mencit jantan setelah diberikan ekstrak etanol kulit petai pada hari ke-21 adalah dosis I (77,52 %) lebih besar dibandingkan dengan dosis II (69,5 %) dan dosis III (73,37 %). Data yang diperoleh dianalisis dengan uji Two Way Anova dengan program SPSS 17. Hasil penelitian ini menunjukkan bahwa pemberian ekstrak etanol kulit petai untuk tiga variasi dosis menyatakan perbedaan yang bermakna secara statistik terhadap penurunan kadar glukosa darah mencit jantan.</p><p><em>Petai (Parkia speciosa Hassk) has a compound β-sitosterol and stigmasterol that have efficacy to decreased blood glucose levels. This study aimed to determine the effect of ethanol extract of petai peel for decrease blood glucose levels of male mice induced by alloxan. Experimental animals were divided into 5 groups including negative control group, positive control group, the first dose (280 mg/kg in mice), the second dose (560 mg/kg in mice), the third dose (840 mg/kg in mice). The study was conducted for 21 days. After 21 days, the result found that the percentage of blood glucose levels after the male mice given the ethanol extract of petai peel was, the first dose (77.52%) biger than the second dose (69.5%) and the third dose (73.37%). The data obtained were analyzed by Two Way ANOVA using SPSS 17. The results showed that have signicantly difference between three dose variation of ethanol extract of petai peel in blood glucose levels.</em></p>

P–060 Dose- dependent mitigation of lead acetate toxicity in males on embryo development in female mice

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
P Dolati ◽  
M J Zamiri ◽  
A Akhlaghi ◽  
Z Jahromi
Keyword(s):  
Adverse Effects ◽  
Embryonic Development ◽  
Embryo Development ◽  
Lead Acetate ◽  
Endocrine System ◽  
Cell Number ◽  
The Other ◽  
Control Group ◽  
Male Mice ◽  
Female Mice

Abstract Study question Does quercetin (75 or 100 mg/kg BW/day) co-administration with lead acetate to male mice affects embryonic development in female mice? Summary answer The low-dose quercetin (75 mg/kg BW/day) ameliorated the adverse effects of lead acetate on mouse embryogenesis. What is known already Lead causes male infertility by impacting on endocrine system and spermatogenesis, and may exert undesirable effects on the offspring. The currently approved treatment for lead poisoning is the use of chelating agents, which form an insoluble complex with lead and shield it from biological targets; thus, reducing its toxicity. One of the main mechanisms of lead-induced toxicity is oxidative stress, and it has been reported that natural antioxidants can reduce the heavy metals toxicity. The aim of the present study was to examine the protective effects of quercetin on the toxicity induced by lead acetate on the embryogenesis in mice. Study design, size, duration Sexually mature (eight-week-old) NMRI male mice (n = 24) were randomly divided into four groups (n = 6 per group) receiving (i) distilled water (control group); (ii) lead acetate (150 mg/kg BW/day) dissolved in deionized water (LA); (iii) lead acetate (150 mg/kg BW/day) + quercetin (75 mg/kg BW/day) (LQ75); (IV) lead acetate (150 mg/kg BW/day) + quercetin (100 mg/kg BW/day) (LQ100). Treatments were applied daily as oral gavages for one cycle of the seminiferous epithelium (35 days). Participants/materials, setting, methods At the end of treatment administration, the males were joined with super-ovulated females, and the retrieved zygotes were cultured for evaluation of the embryo development (at 2-cell, 4-cell, 8-cell, and blastocyst stages), and blastocyst cell number using differential staining (propidium iodide and bisbenzimide). After incubation of capacitated sperm with oocytes, an ultraviolet light microscope was used following 3 min incubation with 25 µg⁄mL bisbenzamide solution for fertilization assessment. Main results and the role of chance Lead acetate (LA) treatment of male mice decreased the 2-cell stage compared with the control group (P &gt; 0.05). There was no difference between control and LQ75, and between LA and LQ100. The other stages of embryonic development were not significantly affected by the treatment. Overall, early embryonic development in the control and LQ75 mice were better than LQ100 and LA mice. The number of cells in the trophectoderm and inner-cell mass were not affected by treatments. However, the total blastocyst cell number in the control was higher than in the other groups; there was no significant difference between LQ100, LQ75 and LA groups. Fertilization rate was not affected by the treatments (P &lt; 0.05). Quercetin acts as a potent antioxidant at low doses, but at high doses exerts a pro-oxidant action. According to previous reports, higher concentrations of quercetin increased apoptosis and necrosis while decreasing the activities of the antioxidant enzymes. Also, it has been suggested that quercetin might disrupt the endocrine system and interfere with Sertoli cell function and sperm motility. Limitations, reasons for caution A limitation of this study is narrow dose selection; more studies are needed to determine the effective dose of quercetin in ameliorating the lead toxicity. There are also side effects of lead-quercetin chelates such as metal redistribution, essential metal loss, accumulation and persistency in intracellular sites, and peroxidation. Wider implications of the findings: Lead administration adversely impacted on the embryogenesis; on the other hand, paternal quercetin co-administration somewhat ameliorated the adverse effects of lead on mice embryogenesis. Trial registration number Not applicable

scholarly journals Ketoksikan Akut dari Ekstrak Etanolik Daun Jarak Pagar (Jatropa curcas) pada Mencit Jantan Galur Balb/C

2014 ◽  
Vol 15 (1) ◽  
pp. 52
Author(s):  
Hanif Nasiatul Baroroh ◽  
Eka Prasasti Nur Rachmani
Keyword(s):  
Acute Toxicity ◽  
Ethanolic Extract ◽  
Negative Control ◽  
Male Mice ◽  
Animal Test ◽  
Group I ◽  
Liver And Kidney ◽  
Single Dosage ◽  
Histopathology Examination ◽  
Lung And Kidney

The acute toxicity of Jatropa curcas leaves on Balb/C male mice was studied in rats. This research aimed to determine acute toxicity, evaluate spectrum of toxic effect and mechanism that caused the death of animal test after administration of ethanolic extract of J. curcas leaves, single dosage orally on 24 hours observation. The research used male mice, which are divided into 5 groups. Group I was negative control with CMC-Na. Group II, III, IV, and V were given extract with dose of 1400 mg/kgBW, 2240 mg/kgBW, 3584 mg/kgBW and 5734 mg/kgBW, respectively. Evaluation of the toxic symptoms and death of animal test was done for 24 hours. If the animal test was died before 24 hours then it underwent surgery to take the heart, liver, lung, and kidney. In the end of the evaluation, all mice were killed to take the vital organs for histopathologic examination. No mortality was observed during study. The test resulted LD50 of ethanolic extract from J. curcas leaves using Balb/C male mice was 5734 mg/kg of BW. It was categorized as practically not toxic. Administration of the extract did not cause alterations of animal behaviours. Histopathology examination shows inflammation in lung, liver, and kidney after administration of the extract.

scholarly journals Efektivitas Ekstrak Artemisia vulgaris L. sebagai Hepatoprotektor pada sel-sel Hati Tikus yang Diinduksi Niasin

2018 ◽  
Vol 6 (2) ◽  
pp. 251
Author(s):  
Laily Rahmawati ◽  
Erma Sulistyaningsih ◽  
Rosita Dewi
Keyword(s):  
Treatment Group ◽  
Liver Damage ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Artemisia Vulgaris ◽  
Group I ◽  
Group Ii

  The niacin in energy drinks has metabolic product that cause oxidative stress and liver damage, while the liver damage can be prevented by hepatoprotective agents. Scoparone in Artemisia vulgaris L. can act as a hepatoprotector by its antioxidant effect. This study aimed to investigate the effectivity of Artemisia vulgaris L. extract as a hepatoprotector in wistar hepatocytes induced by niacin. This study used 25 male rats which were divided into 5 groups: normal, the negative control, the positive control, the treatment group I, and II. Treatment was conducted for 28 days. The samples were terminated and the hepatocyte were prepared for histological examination. Histological appearance was catagorized as mild, moderate, and severe damage with or without inflamatory cells activity. The data analysis by Kruskal Wallis showed significant difference (p<0,001). Further analysis by Mann Whitney revealed significantly difference (p<0,05) between normal group and all groups, negative control group and positive control group, and positive control group and treatment group I, but not significantly difference between negative control group and treatment group I, negative control group and treatment group II, positive control group and treatment group II, and between treatment groups. The study concluded that the effectivity of Artemisia vulgaris L. extract has not been proven as a hepatoprotector but further study is needed to draw a definite conclusion.   Keywords: energy drink, niacin, Artemisia vulgaris L., hepatoprotector  

scholarly journals Anti-nociceptive Potential of Ethanol Extract of Terminalia macroptera Guill&Perr (Combretaceae) Stem Bark in Mice

2021 ◽  
Vol 16 (2) ◽  
pp. 13-21
Author(s):  
S.A. Atunwa ◽  
M.O. Amali ◽  
S.O. Lawal ◽  
S.O. Usman ◽  
A.I. Olapade
Keyword(s):  
Acetic Acid ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Stem Bark ◽  
Negative Control ◽  
Flowering Plant ◽  
Control Group ◽  
Group I ◽  
Tail Immersion ◽  
Dose Dependent

Background: Terminalia macroptera Guill. &Perr. (Combretaceae) is a flowering plant with several ethno-medicinal claims. However, the dearth of information on its analgesic property has necessitated this study.Objectives: to evaluate the anti-nociceptive potential of ethanol extract of Terminalia macroptera stem bark (TMSB) in mice.Materials and Methods: Male and female mice of weight range 22 – 25g were randomly allotted into seven groups (n= 5) and treated as follows: Group I received 0.5 mL distilled water orally (negative control), Groups II-V were orally administered ethanol extract of T. macroptera stem bark (TMSB) at 50, 100, 200, and 400 mg/kg respectively while groups VI-VII received piroxicam 10 mg/kg and pentazocine 2 mg/kg intraperitoneally respectively as standards. The same treatment pattern was adopted for both pain models: tail immersion and acetic acid-induced writhing assays. Data were expressed as mean ± standard error of mean (SEM) using two-way analysis of variance (ANOVA) followed by Tukey’s and Bonferroni's multiple comparisons tests with p < 0.05 taken as significance.Results: The ethanolic extract of Terminalia macroptera stem bark showed significant dose-dependent anti-nociceptive activity at 100 and 400 mg/kg (2.95±0.41 and 2.9±0.31 respectively) 60 min post-treatment compared to the negative control group in the tail immersion test. Significant inhibition of nociception (0.20±0.20) was obtained at 400 mg/kg compared to the negative control group in the acetic acid-induced writhing test.Conclusions: The ethanol extract of Terminalia macroptera stem bark exhibited dose-dependent anti-nociceptive potential in both tail immersion and acetic acid-induced writhing assays in mice.

scholarly journals The safety of tea agarwood (Aquilaria malaccensis) from tree induction through test of toxicity subchronic oral 90 days

2017 ◽  
Vol 14 (2) ◽  
pp. 69-76
Author(s):  
RIDWANTI BATUBARA ◽  
SURJANTO SURJANTO ◽  
TAHAN MANGARANAP SIHOMBING ◽  
HERAWATY GINTING
Keyword(s):  
Clinical Symptoms ◽  
Laboratory Animals ◽  
Control Group ◽  
Male Mice ◽  
Tea Leaves ◽  
Subchronic Toxicity ◽  
Female Mice ◽  
Aquilaria Malaccensis ◽  
Repeated Doses ◽  
Histopathological Results

Batubara R, Surjanto, Sihombing TM, Ginting H. 2016. The safety of tea agarwood (Aquilaria malaccensis) from tree induction throuht test of toxicity subcronic oral 90 days. Biofarmasi 14: 69-76. Subchronic toxicity test is a test to detect the toxic effect that arises after the administration of the test reparation with repeated doses were given orally to the tested animal for 28 or 90 days. Leaves agarwood (Aquilaria malaccensis Lamk) is a tree from a tribe Thymeleaceae, already started popular used the farmer agarwood in Langkat as a drink that in pour. The result of an interview with the farmer agarwood explained that consume tea from the leaves agarwood of this kind of have many benefits include improve canal. To that was done the research security against the tea leaves agarwood induction taken from agriculture agarwood in Langkat, Sumatera North through test toxic subchronic oral. This study aims to determine the symptoms of toxic posed by product tea agarwood induction. This study used laboratory animals that male mice and female mice were divided into 5 groups, namely the 130, 260, 390, 520 mg/kgBW and the control group. The observation of clinical symptoms indicate the presence of toxic symptoms of weakness, changes in fur and agitated at doses of 390 and 520 mg/kgBW in male mice and female mice, the observation macropathology organs alloxan still normal the red-brown, the surface of slippery and consistency chewy. Histopathological results showed hemoglia and dilation of the blood vessels in all groups. Results showed that mice were given tea steeping agarwood induction doses ranging from 130, 260,390 and 520 mg/kgBW there are no mice died, so it can be concluded that the administration of agarwood tea steeping in mice does not cause toxic symptoms and safe for consumption.

scholarly journals Effect of aqueous Extract of Terminalia bellirica fruit pulp on Alcohol affected learning in swiss albino mice

2021 ◽  
Vol 6 (2) ◽  
pp. 76-78
Author(s):  
Sowmya ◽  
Manohar VR ◽  
Mohandas Rai ◽  
H N Gopalakrishna ◽  
Chandrashekar R
Keyword(s):  
Aqueous Extract ◽  
Protective Action ◽  
Negative Control ◽  
Control Group ◽  
Acute Administration ◽  
Aqueous Extracts ◽  
Swiss Albino Mice ◽  
Alcohol Administration ◽  
Group I ◽  
Albino Mice

To evaluate the effect of Aqueous extract of Terminalia belliricafruit pulp (AETB) on learning by Hebb William maze model in mice with acute alcohol consumption.Swiss albino mice (n=48) of either sex weighing 20-30g will be divided into eight groups of six mice each. Drugs were given orally after 12 hours of fasting. Group I mice received 10ml/kg of Normal Saline, Group II mice received Piracetam 200mg/kg, Group III received AETB 36mg/kg, Group IV received ethanol 1.5g/kg orally, Group V received ethanol(1.5g/kg )+ piracetam (200mg/kg), Group VI mice received ethanol(1.5g/kg) +AETB(9mg/kg), Group VII mice received ethanol(1.5g/kg) +AETB (18mg/kg), Group VIII mice received ethanol(1.5g/kg) +AETB(36mg/kg). Time taken by the animal to reach the reward chamber from the start chamber (TRC) in Hebb-William maze was used as a parameterto evaluate the learning.Acute alcohol administration showed increase in TRC. Whereas, acute administration of Aqueous extracts of Terminalia belliricafruit pulp showed a decrease in TRC when compared to the control group. The TRC values for the groups that were administered AETB along with acute alcohol administration showed decrease in TRC values compared to the negative control.Current study showed acute alcohol administration caused impairment of thelearning ability in mice. Whereas, acute administration of Aqueous extracts of Terminalia belliricafruit pulp (AETB)caused enhancement of learning. Pre-treatment with AETB before acute alcohol administration indicated protective action of AETB on alcohol affected learning in mice.

TOTAL FLAVONOID DAN EFEKTIVITAS EKSTRAK ETANOL BIJI KELOR (Moringa oleifera L) ASAL KOTA PALU SULAWESI TENGAH TERHADAP HISTOPATOLOGI PANKREAS TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI STREPTOZOTOCIN

2020 ◽  
Vol 6 (1) ◽  
pp. 24
Author(s):  
Viani Anggi ◽  
Joni Tandi ◽  
Veronika Veronika
Keyword(s):  
Ethanol Extract ◽  
Negative Control ◽  
Total Flavonoid ◽  
Male Rats ◽  
Control Group ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
White Rats ◽  
Group I ◽  
Streptozotocin Induced Diabetes

This study aims to determine the content of flavonoid and the effect of ethanol extract of moringa seeds on the regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes. This study method used has total flavonoid equivalent quercetin by spectrophotometry uv-vis and to regeneration of pancreatic β cells in male white rats used 30 test animals,namely male white rats divided into 6 groups, each group consisted of 5 male white rats with details of group I as normal control, Group II as negative control given 0.5% Na-CMC suspension, Group III as positive control given glibenclamide suspension and in Groups IV, V, and VI were given with each dose of 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BB. Histopathological damage picture of the pancreas was observed by staining HE using a 400x magnification olympus Cx21 microscope. The results showed that the ethanol extract of moringa seeds contained secondary metabolites, namely flavonoids, alkaloids, saponins and tannins. The results showed has total flavonoid equivalent quercetin of moringa seeds is 1,26% and regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes of Moringa seed ethanol extract at a dose of 400 mg/kg BB can have an effect on the regeneration of β cells in the pancreas of white diabetic male rats.  

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