Preparation of the copper-containing metallogels based on chitosan for biomedical and agricultural applications

2020 ◽  
Vol 1 (8) ◽  
pp. 60-70
Author(s):  
A. A. Vikhrov ◽  
◽  
V. P. Zubov ◽  
S. Yu. Zaytsev ◽  
◽  
...  

It is well-known, due to the geological features in a number of regions of the Russian Federation, there may be a shortage of certain microelements and other important “nutrients” in animal diets. The main approach to solve this problem is to use special feed additives. At present, preparations based on organic sources, for example, metal-polymer complexes, are considered a promising alternative. The purpose of this study is to develop an improved method for preparation of the copper-containing polysaccharide complexes and to study their most important parameters. Using CuCl2 as an example, it was shown that the formation of chitosan hydrogels is possible without the usage of potentially hazardous cross-linking agents (for example, glutaraldehyde) or polyvalent anions (for example, SO4 2–), which provide non-covalent cross-linking of chitosan due to electrostatic interactions with NH3 + in its composition. It was found that, upon frontal «gelation» of a 2% chitosan solution (MM 400±100 kDa) in acetic acid (1 vol%), the formation of stable metal gels is observed provided that the content of CuCl2 and ethanol in the precipitant solution is more than 40 mg/ml or more than 24 vol.%, respectively (Vchitosan = Vprecipitant). The obtained complexes are stable in aqueous-alcoholic solutions and swell in water up to destruction (pH 5,5). After additional treatment with an aqueous 1,5% ammonia solution, complexes practically do not swell in solutions with ≥ pH 5,5 (at least τ = 6 days) and dissolve at pH ≤ 4,2. Thus, the use of these complexes is able to provide the release of Cu2 + not in the rumen (pH 6,3–7,2), but in the abomasum (pH ~ 3), which can increase the bioavailability of copper. The development of an improved method for obtaining metal-polysaccharide complexes in a gel form that does not contain «ballast» (in terms of nutritional value and physiology of farm animals) anions (for example, SO4 2–) opens up new opportunities for the development of highly effective feed additives for animal husbandry.

Author(s):  
Yevhen Rudenko ◽  
Victoria Kunets

An attempt is made to concentrate this research in the field of the scientific heritage of Academician UAAS G. Bogdanov, due to certain retrospective and prospective reasons. The main scientific research of Bogdanov O. devoted to the development of theoretical bases of animals’ feeding farms, technologies of feed production and use were carried out in the period connected with work at the Research Institute of Animal Husbandry of the Forest-Steppe and Polissya of the USSR (1956–1976, now the Institute of Animal Husbandry NAAS). Developing the theoretical and practical positions of the classics of domestic zootechnical science I.Belgovsky and P. Pshenichny, Academician G. Bogdanov together with the scientific school created by him laid the foundation for the domestic and made a significant contribution to the world science of farm animal feeding and technology production of high quality feed. The creative heritage of the scientist includes patterns of energy, protein, amino acid, mineral, vitamin nutrition of cattle, pigs, sheep; norms and technologies of full-fledged feeding of farm animals; theoretical bases of formation of meat productivity of cattle in ontogenesis and substantiation of breed technologies of intensive beef production in Ukraine. The result long period of work of the scientist and his colleagues was represented in 2012 of the conceptual work "Theory and practice of normalized feeding of cattle". Research in the physiology and biochemistry of ruminants has led to the creation of new concepts for the evaluation of feed protein and protein rationing for highly productive animals, which gave impetus to the development of innovative feed additives based on protected protein and starch. Given the topic of our article, the work of the scientist, dedicated to the feeding of highly productive cattle, is singled out and considered.


2019 ◽  
Vol 19 (1) ◽  
pp. 46-49 ◽  
Author(s):  
O. KARUNKYI ◽  
T. REZNIK ◽  
Ye KULIDZHANOV

The animal husbandry cannot develop successfully without complete balanced feed and optimal forage supply. This article deals with the chemical composition of chlorella suspension. The ration is balanced with seaweeds as well as premixes, vitamins and bio supplement for the last decades. These seaweeds include chlorella - a representative of green microscopic algae. The use of chlorella allows for multi-factor balancing of the diet in accordance with modern feeding standards, which increases the productive effect of feed and significantly increases the transformation of nutrients into livestock products. This is arelevant issue of modern animal husbandry. The chlorella suspension was material for scientific research. It was made on the farm “In Samvel”, Ovidiopol District. According to the result of researches that took place on the farm " In Samvel", Biliayevka District, Odessa Oblast and SERF "Yuzhnyi" OSAGES NAAS, new data concerning chemical composition, the positive influence of investigated chlorella suspension on the growth and development of finishing pigs as well as feed costs by 1 kg of growth were obtained. It has been established that the chemical composition of chlorella suspension takes a special place among all feed additives used in farm animals feeding. It has been established that the additional use of chlorella suspension in the ration of finishing pigs of Large White breeds contribute to the increase of average daily gains by 121.9% against the control group in which chlorella suspensions was not given. Feed conversion to obtain1 kg of pigs live weight gain in the control group was 5.1 kg, in the experimental group - 4.2 kg and feed conversion index in the experimental group was higher by 21.4%. Thus the results of researches indicate the positive effect of investigated chlorella suspension on the growth anddevelopment of finishing pigs. Due to the obtained results, we can state that the chemical composition of the suspension chlorella takes a special place among all feed additives used in farm animals feeding. Chlorella has higher indicators of chemical composition, the amount of protein, vitamins and minerals in comparison with plant fodder and crops of agricultural production.


1970 ◽  
pp. 134-144
Author(s):  
L. M. Kryzhak ◽  
N. V. Hutsol ◽  
O. O. Mysenko

Purpose. To reveal the features and expediency of using feed additives of plant origin, which have a positive effect on the health and productivity of animals. To substantiate scientific and practical approaches of the medicinal plants use in animal husbandry in the form of a sterilized herbal brew, extracts, dry components of medicinal plants, which will have preventive and medicinal properties for animals, especially young. Methods. Analytical methods of research, observation, comparison, analysis. Results. Herbal preparations are of little toxicity and contribute to a high therapeutic effect. Their use in the diets of farm animals and poultry is predetermined by the presence in their composition, in addition to food, biologically active substances, which, when ingested, even in small quantities, cause a specific physiological effect. Dietary supplements for farm animals and poultry with a preventive effect, which improve health, increase productivity and enrich rations with feed additives of various natures, are of great importance. Based on the research carried out, biologically active additives will be created for the use in feeding farm animals and poultry in order to normalize digestion process, regulate metabolism, boost immune system. Conclusions. Assessment of the effect of using medicinal plants as biologically active additives to the diets of farm animals has been carried out. Influence of medicinal plants on the immune system and health of animals, treatment and prevention of infectious diseases, milk quality and productivity of dairy cows, improving the taste of poultry meat and young pigs livability was studied.


2020 ◽  
Vol 27 ◽  
pp. 00018
Author(s):  
Lyubov L. Zakharova ◽  
Georgiy A. Zhorov ◽  
Vasiliy I. Dorozhkin ◽  
Viktor N. Obryvin ◽  
Natalya A. Brichko

The impact of human economic activity on the environment is increasingly taking the form of combined pollution with various ecotoxicants including xenobiotics of radiation (caesium-137, strontium-90) and chemical (mercury, cadmium, lead and other toxic elements) nature. Today, this is one of the most urgent and insufficiently studied scientific problems. At current levels of systematic intake and accumulation of ecotoxicants in the body of productive animals, various anthropogenic and environmental organopathologies and diseases develop, and the risk of obtaining products that are dangerous to the consumer increases. In this regard, in the conditions of combined technogenic pollution of agroecosystems, it is necessary to solve the problem of ensuring the production of safe and biologically complete livestock products and maintaining the health and useful qualities of farm animals. The article presents the results of research on the development of compositions and technologies for the use of sorption-detoxifying complexes in the form of feed additives to reduce the accumulation and negative effects of ecotoxicants on the animal body and ensure the production of safe products.


Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 466
Author(s):  
Herbert Galler ◽  
Josefa Luxner ◽  
Christian Petternel ◽  
Franz F. Reinthaler ◽  
Juliana Habib ◽  
...  

In recent years, antibiotic-resistant bacteria with an impact on human health, such as extended spectrum β-lactamase (ESBL)-containing Enterobacteriaceae, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE), have become more common in food. This is due to the use of antibiotics in animal husbandry, which leads to the promotion of antibiotic resistance and thus also makes food a source of such resistant bacteria. Most studies dealing with this issue usually focus on the animals or processed food products to examine the antibiotic resistant bacteria. This study investigated the intestine as another main habitat besides the skin for multiresistant bacteria. For this purpose, faeces samples were taken directly from the intestines of swine (n = 71) and broiler (n = 100) during the slaughter process and analysed. All samples were from animals fed in Austria and slaughtered in Austrian slaughterhouses for food production. The samples were examined for the presence of ESBL-producing Enterobacteriaceae, MRSA, MRCoNS and VRE. The resistance genes of the isolated bacteria were detected and sequenced by PCR. Phenotypic ESBL-producing Escherichia coli could be isolated in 10% of broiler casings (10 out of 100) and 43.6% of swine casings (31 out of 71). In line with previous studies, the results of this study showed that CTX-M-1 was the dominant ESBL produced by E. coli from swine (n = 25, 83.3%) and SHV-12 from broilers (n = 13, 81.3%). Overall, the frequency of positive samples with multidrug-resistant bacteria was lower than in most comparable studies focusing on meat products.


Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1542
Author(s):  
Marta Michalak ◽  
Konrad Wojnarowski ◽  
Paulina Cholewińska ◽  
Natalia Szeligowska ◽  
Marcel Bawej ◽  
...  

In recent years, a boost in the ruminant population has been observed, and consequently, an increase in the animals’ demand for nutrients and methane emissions. Methane emission is generated during the microbial fermentation of feed in the rumen, and a percentage even up to 12% of the energy obtained by this process can be wasted. In addition, the use of antibiotics in animal husbandry is being increasingly restricted. restricted. As a result, there is a continuous search for innovative feed additives that can serve as alternatives to antibiotics, and will also be safe for both people and the environment. In the present review article, additives were selected on basis that, according to studies conducted so far, may positively affect the microbiome of the digestive system by improving indicators and/or reducing methane production. Among them, probiotics, prebiotics or their combination—synbiotics are at the forefront of research. However, additives in the form of algae or plant origin are also gaining ground in popularity, such as essential oils, fermented wheat straw or Gelidium amansii, due to their general recognition as safe (GRAS) for both humans and environment.


Author(s):  
T. A. Krasnoshchekova ◽  
E. Yu. Zalyubovskaya

The determining factor in increasing the productivity of farm animals is the provision of comlete feeding of animals through feed additives. Among the functional feed additives containing essential trace elements, a special place under the conditions of the Amur region is given to microadditives of selenium, iodine and cobalt. The Amur region belongs to the biogeochemical region in which the defi ciency of I, Se and Co in feed is from 80 to 95 % compared to the average Russian indicators. The purpose of the work was to compare the eff ect of feed additives made from red alga Ahnfeltia, soy protein asparaginates separately and together with the drug “Creamino” on the growth, development and metabolism of young cattle. Under the conditions of the Amur region on the basis of their own experimental data in the rearing of young cattle, the eff ectiveness of the use of the drug “Creamino” and red alga Ahnfeltia has been scientifi cally justifi ed. The conducted scientifi c and economic and physiological experiments allowed us to determine the eff ect of red anfel on the growth and development, metabolic processes of replacement heifers and the growth rate of steers when they were fed soy protein asparaginates together with the drug “Creamino”. The evaluation of the economic effi ciency of feeding heifers I, Co and Se in organic form as part of soy protein asparaginates and red alga Ahnfeltia has shown a higher economic eff ect per 1 head per day in the 2nd experimental group, where the level of profi tability was 28,6 %. The results of the research and production experiment on steers have shown that from an economic point of view, it is advisable to use I, Co and Se in their rations in the form of soy protein asparaginates together with the drug “Creamino”, feeding of which can signifi cantly increase the economic eff ect, which is 1 head per day of 4,47 rubles with a profi tability level of 31,0 %.


2020 ◽  
Vol 33 (3) ◽  
pp. 373-381 ◽  
Author(s):  
Hujaz Tariq ◽  
Amit Sharma ◽  
Srobana Sarkar ◽  
Lamella Ojha ◽  
Ravi Prakash Pal ◽  
...  

There is a need for newer feed additives due to legal prohibition on inclusion of growth promoting antibiotics in livestock diets in several countries due to antimicrobial resistance. In this context, rare earth elements (REE) have gained attention among animal nutritionists as potential growth promoters. Currently, several studies have reported better weight gain, milk production, egg laying capacity and feed conversion efficiency among different breeds of farm animals following supplementation with REE, with however largely inconsistent results. Furthermore, REE supplementation has also shown to improve ruminal fibrolytic and proteolytic activities as well as flavor of meat with negligible residues in edible tissue, however the mechanism behind this action is still unclear. According to existing research, due to their poor absorption and similarity with calcium REE might exert their action locally on gut microbial populations within the gastrointestinal tract (GIT). Moreover, REE have also shown anti-inflammatory, anti-oxidative as well as immune stimulating effects. The present review aims to broaden the knowledge about use of REE as feed additives for livestock and sum up efficacy of REE supplementation on performance and health of animals by comparing the findings. Till date, researches with REE have shown properties that make them a promising, new and safe alternative feed additive but further exploration is recommended to optimize effects and clarify discrepancy of various results before practical proposals can be drafted.


2021 ◽  
Vol 16 (2) ◽  
pp. 134-144
Author(s):  
S. M. Yessengaliyeva ◽  
M. A. Mansurova ◽  
A. D. Makhmudov ◽  
L. V. Fedorchenko

The article is devoted to the study and analysis of the current state of the animal husbandry industry in the Republic of Kazakhstan in the context of regions. The indicators of the dynamics of the number of livestock of farm animals for the period 2015-2019 by regions, indicators of productivity in the industry, indicators of the volume of production of meat products are analyzed. The dynamics and structure of costs in the country’s livestock industry are also considered.Today, one of the most pressing problems in the development of the agro-industrial complex is the low level of labor productivity due to low automation and digitalization of technological processes. The need to meet the demand for livestock products in the domestic market of the Republic of Kazakhstan, as well as to increase its export resources, poses a challenge for Kazakhstani science and practice to develop, scientifically substantiate and master modern technologies for the production of low-cost, environmentally friendly, competitive products of the industry. They should be resource-saving, aimed at maximizing the use and improvement of the genetic potential of farmed farm animals, adapted to the specific natural and economic conditions of the regions of the republic. The development and mastering of such technologies will make it possible to weaken the negative impact of the industry on the environment, reduce the cost of material resources, and effectively use the available land and water resources [5].The main problems hindering the effective development of the country’s livestock industry are identified. The promising strategic directions for the development of this industry have been determined. From the point of view of experts of the financial organization, the country has good potential and opportunities to export its beef and pork to China, and the lamb of the Edilbay sheep breed to the countries of the Middle East.


PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11934
Author(s):  
Jiashun Chen ◽  
Fang Wang ◽  
Yexin Yin ◽  
Xiaokang Ma

Garlic (Allium sativum) is an essential vegetable that has been widely utilized as seasoning, flavoring, culinary and in herbal remedies. Garlic contains several characteristic organosulfur compounds, such as diallyl sulfide, allicin (diallyl thiosulphate), γ-glutamylcysteine, and S-allyl cysteine (alliin) and ajoene, which garlic has beneficial effects on inflammation, oxidative stress markers, hypertension, hyperlipidaemia and endothelial function in vitro or in animal model. These bioactive molecules are also playing pivotal role in livestock and fisheries production apart from its application in humans. Supplementation of animal feed with garlic and its related products is consistent with the modern agricultural concept of organic animal husbandry. This review compiles the information describing the effects of feeding garlic and its extracts on selected performance parameters in animals (chicken, rabbits, ruminants, pigs and fish). This review may provide reference for scientists and entrepreneurs to investigate the applications of feeds added with garlic and allicin by-products for the improvement of animal husbandry and aquatic production.


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