scholarly journals Hematological profiles of visceral leishmaniasis patients before and after treatment of anti-leishmanial drugs at University of Gondar Hospital; Leishmania Research and Treatment Center Northwest, Ethiopia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Elias Shiferaw ◽  
Fadil Murad ◽  
Mitikie Tigabie ◽  
Mareye Abebaw ◽  
Tadele Alemu ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Blood Cell ◽  
Pearson Correlation ◽  
Hematological Parameters ◽  
Parasite Load ◽  
Treatment Center ◽  
Rank Test ◽  
P Value ◽  
Before And After ◽  
The Mean

Abstract Background Visceral leshimaniasis is a parasitic disease characterized by systemic infection of phagocytic cells and an intense inflammatory response. The progression of the disease or treatment may have an effect on hematological parameters of these patients'. Thus, the current study sought to compare the hematological profiles of visceral leishmaniasis patients before and after treatment with anti-leishmaniasis drugs. Method An institutional-based retrospective cohort study was conducted among visceral leishmaniasis patients admitted to the University of Gondar comprehensive specialized referral hospital leishmaniasis research and treatment centre between September 2013 and August 2018. Hematological profiles were extracted from the laboratory registration book before and after treatment. Data were entered to Epi-info and exported to SPSS for analysis. Descriptive statistics were summarized using frequency and percentage to present with the table. The mean, standard deviation, median, and interquartile range were used to present the data. Furthermore, using the paired t-test and the Wilcoxon Signed rank test, the mean difference for normally and non-normally distributed data was compared. Spearman and Pearson correlation analysis were used to describe the relationship between hematological parameters and various variables. A P value of 0.05 was considered statistically significant. Result With the exception of the absolute neutrophil count, all post-treatment hematological parameters show a significant increase when compared to pre-treatment levels. Prior to treatment, the prevalence of anemia, leukopenia, and thrombocytopenia was 85.5, 83.4, and 75.8%, respectively, whereas it was 58.3, 38.2, and 19.2% following treatment. Furthermore, parasite load was found to have a statistically significant negative correlation with hematological profiles, specifically with white blood cell and red blood cell parameters. Conclusion According to our findings, patients with visceral leishmaniasis had improved hematological profiles after treatment. The effect of treatment on parasite proliferation and concentration within visceral organs, in which the parasite load could directly affect the patient's hematological profiles, may be associated with the change in hematological profiles.

Hematological alteration among visceral leishmaniasis patients attending in Western Tigrai, Ethiopia, 2018/2019: A cross-sectional study

2020 ◽  
Author(s):  
Gebremedhin Gebremichail ◽  
Brhane Tesfanchal ◽  
Getachew Belay ◽  
Gebreslassie Gebremariam ◽  
Gebreyohans Teklehaymanot ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Blood Cell ◽  
Hematological Parameters ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Control Groups ◽  
Cross Sectional ◽  
Red Cell Indices ◽  
Hematological Abnormalities

Abstract Background: Hematological abnormalities are common in visceral leishmaniasis patients, which is one of the main public health problems worldwide. The most common hematological abnormalities are anemia, leucopenia and thrombocytopenia. Therefore, this study aimed to assess the hematological alteration among visceral leishmaniasis patients attending Western Tigrai, Ethiopia, 2019. Method: Hospital based comparative cross sectional study was conducted from November 2018 to March 2019 in Western Tigrai, Ethiopia. A total of 100 Visceral Leishmaniasis patients and 100 control groups were included in this study. Blood was collected and analyzed by mindray BC-5800 hematology analyzer. Data was entered and analyzed using Statistical package for social science version 23. Student independent t-test was used for data analysis. P value <0.05 was considered as statistically significant at 95% confidence level. Result: From the total 100 visceral leishmaniasis patients the following abnormalities were reported: 96(96%) anemia, 95(95%) leucopenia, 92(92%) neutropenia, 73(73%) Lymphopenia, 45(45%) eosinopenia and 97(97%) had thrombocytopenia. Red blood cell, hemoglobin, hematocrit, red cell indices and platelet were significantly lower (p<0.05) in visceral leishmaniasis patients compared with the control groups. Similarly the total White blood cell, neutrophil, lymphocyte, eosinophil and basophil count were significantly lower (p<0.05) in visceral leishmaniasis patients compared with the control groups. Conclusion: The major changes in peripheral blood of patient with visceral leishmaniasis are reduced number of red blood cells, reduction in leukocytes and decreased platelet count. Visceral leishmaniasis patients presented with anemia, leucopenia and thrombocytopenia. So this finding indicates that visceral leishmaniasis causes alterations of hematological parameters. Key words: Amastigote, Anemia, Hematological Parameters, Promastigote, Visceral leishmaniasis, Ethiopia .

scholarly journals Pengaruh Hemodialisis terhadap Urea Reduction Ratio pada Pasien Penyakit Ginjal Kronik Stadium V di RSUP Dr. M. Djamil Padang

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Wahyuni Armezya ◽  
Ellyza Nasrul ◽  
Elizabet Bahar
Keyword(s):  
Kidney Diseases ◽  
Pearson Correlation ◽  
Experimental Studies ◽  
Hemodialysis Patients ◽  
Reduction Ratio ◽  
Bivariate Analysis ◽  
P Value ◽  
Before And After ◽  
The Mean ◽  
Urea Reduction Ratio

Abstrak Pravelensi pasien penyakit ginjal kronik stadium V yang mendapat terapi hemodialisis terus meningkat di dunia. Dosis hemodialisis yang diberikan kepada pasien harus mencukupi kebutuhan tubuh agar tujuan terapi dapat tercapai dengan baik. Tujuan penelitian ini adalah untuk menentukan pengaruh hemodialisis terhadap Urea Reduction Ratio (URR). Penelitian secara eksperimental kuasi dilakukan pada 55 pasien hemodialisis sejak Agustus 2013 sampai Maret 2014. Data dikumpulkan dari rekam medik dan hasil pemeriksaan ureum sebelum dan sesudah hemodialisis. Analisis bivariat menggunakan uji t berpasangan dan korelasi Pearson untuk mengetahui perbedaan ureum sebelum dan sesudah hemodialisis serta pengaruh hemodialisis terhadap URR. Berdasarkan data penelitian didapatkan hasil rerata ureum sebelum hemodialisis sebesar 100,27 mg/dl, rerata ureum sesudah hemodialisis 31,17 mg/dl dan rerata URR sebesar 68,80%. Sebanyak 62% pasien mendapatkan hemodialisis yang adekuat dan 38% pasien mendapatkan hemodialisis tidak adekuat. Uji statistik menunjukkan terdapat perbedaan signifikan ureum sebelum dan sesudah hemodialisis (p = 0,0001) dan terdapat pengaruh signifikan hemodialisis terhadap URR (p = 0,0001).Kata kunci: hemodialisis, ureum, URR AbstractThe prevalence of chronic kidney diseases stage V that receive hemodialysis therapy rise in the world. Hemodialysis doses are given to the patient must meet the body’s needs in order to make the therapeutic goals can be achieved well. The objective of this study was to determine the adequacy of hemodialysis measured by URR in hemodialysis patients in the M Djamil hospital Padang. Quasi-experimental studies performed on 55 hemodialysis patients from August 2013 to March 2014. Data were collected from medical records and the results of urea before and after hemodialysis. Bivariate analysis using a paired t test and Pearson correlation urea to know the difference between before and after hemodialysis and hemodialysis influence on the URR. The results showed that the mean of urea levels before hemodialysis is 100.27 mg/dl, the mean of urea levels after hemodialysis is 31.17 mg/dl and the mean of URR is 68,80%. The 62% patients got adequate hemodialysis and 32% patients got inadequate hemodialysis. Based on statistics, obtained p value is 0.0001 showed there are siginificants difference in urea before and after hemodialysis and there are the influence of hemodialysis to URR (p value: 0.0001). Keywords: hemodialysis, urea, URR

Correlation of AGR2 expression with the incidence of metastasis in luminal breast cancer

2021 ◽  
pp. 1-5
Author(s):  
David Samuel Kereh ◽  
John Pieter ◽  
William Hamdani ◽  
Haryasena Haryasena ◽  
Daniel Sampepajung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Mean Value ◽  
Rank Test ◽  
Luminal Breast Cancer ◽  
P Value ◽  
Strong Positive Correlation ◽  
Breast Cancer Patients ◽  
The Mean ◽  
Spearman Test

BACKGROUND: AGR2 expression is associated with luminal breast cancer. Overexpression of AGR2 is a predictor of poor prognosis. Several studies have found correlations between AGR2 in disseminated tumor cells (DTCs) in breast cancer patients. OBJECTIVE: This study aims to determine the correlation between anterior Gradient2 (AGR2) expression with the incidence of distant metastases in luminal breast cancer. METHODS: This study was an observational study using a cross-sectional method and was conducted at Wahidin Sudirohusodo Hospital and the network. ELISA methods examine AGR2 expression from blood serum of breast cancer patients. To compare the AGR2 expression in metastatic patients and the non-metastatic patient was tested with Mann Whitney test. The correlation of AGR2 expression and metastasis was tested with the Rank Spearman test. RESULTS: The mean value of AGR2 antibody expression on ELISA in this study was 2.90 ± 1.82 ng/dl, and its cut-off point was 2.1 ng/dl. Based on this cut-off point value, 14 subjects (66.7%) had overexpression of AGR2 serum ELISA, and 7 subjects (33.3%) had not. The mean value AGR2 was significantly higher in metastatic than not metastatic, 3.77 versus 1.76 (p < 0.01). The Spearman rank test obtained a p-value for the 2 tail test of 0.003 (p < 0.05), which showed a significant correlation of both, while the correlation coefficient of 0.612 showed a strong positive correlation of AGR2 overexpression and metastasis. CONCLUSIONS: AGR2 expression is correlated with metastasis in Luminal breast cancer.

Validation of a Belgian Prediction Model for Patient Encounters at Football Mass Gatherings

2021 ◽  
pp. 1-6
Author(s):  
Kris Spaepen ◽  
Door Lauwaert ◽  
Leonard Kaufman ◽  
Winne AP Haenen ◽  
Ives Hubloue
Keyword(s):  
Pearson Correlation ◽  
First Aid ◽  
Rank Test ◽  
Mean Deviation ◽  
Mass Gatherings ◽  
Actual Patient ◽  
Significant Difference ◽  
Correlation Tests ◽  
The Mean ◽  
Patient Presentation

Abstract Background: To validate the Belgian Plan Risk Manifestations (PRIMA) model, actual patient presentation rates (PPRs) from Belgium’s largest football stadium were compared with predictions provided by existing models and the Belgian PRIMA model. Methods: Actual patient presentations gathered from 41 football games (2010-2019) played at the King Baudouin Stadium (Brussels, Belgium) were compared with predictions by existing models and the PRIMA model. All attendees who sought medical help from in-event health services (IEHS) in the stadium or called 1-1-2 within the closed perimeter around the stadium were included. Data were analyzed by ANOVA, Pearson correlation tests, and Wilcoxon singed-rank test. Results: A total of 1,630,549 people attended the matches, with 626 people needing first aid. Both the PRIMA and the Hartman model over-estimated the number of patient encounters for each occasion. The Arbon model under-estimated patient encounters for 9.75% (95% CI, 0.49-19.01) of the events. When comparing deviations in predictions between the PRIMA model to the other models, there was a significant difference in the mean deviation (Arbon: Z = −5.566, P <.001, r = −.61; Hartman: Z = −4.245, P <.001, r = .47). Conclusion: When comparing the predicted patient encounters, only the Arbon model under-predicted patient presentations, but the Hartman and the PRIMA models consistently over-predicted. Because of continuous over-prediction, the PRIMA model showed significant differences in mean deviation of predicted PPR. The results of this study suggest that the PRIMA model can be used during planning for domestic and international football matches played at the King Baudouin Stadium, but more data and further research are needed.

scholarly journals Aplikasi Web Cek Riska sebagai Upaya Meningkatkan Pengetahuan Ibu Mendeteksi Dini Risiko Tinggi Kehamilan

2020 ◽  
Vol 4 (1) ◽  
pp. 215-221
Author(s):  
Ni Luh Putu Martini ◽  
Irna Nursanti ◽  
Giri Widakdo
Keyword(s):  
High Risk ◽  
Experimental Design ◽  
Web Application ◽  
P Value ◽  
Group Design ◽  
Risk Pregnancy ◽  
Before And After ◽  
Quasi Experimental ◽  
The Mean ◽  
In Pregnancy

This study aimed to determine the effect of the risk checks web application on the knowledge of mothers to detect high risk early in pregnancy. The research design used in this study was a quasi-experimental design with one group design without control. The results showed that the mean difference before and after the intervention was 13.00, with a p-value of 0.000. In conclusion, the risk check web application can increase mothers' knowledge to detect high risk early in pregnancy.   Keywords: Web Application, High-Risk Pregnancy

scholarly journals EFFICACY OF LATERAL WEDGING IN FOOTWEAR IN MEDIAL COMPARTMENT OSTEOARTHRITIS KNEE

2019 ◽  
pp. 1-3
Author(s):  
Suman Badhal ◽  
U. Singh ◽  
S. L Yadav ◽  
Gita Handa
Keyword(s):  
Intervention Group ◽  
Cost Effective ◽  
Mean Difference ◽  
Medial Compartment ◽  
Treatment Modalities ◽  
Rank Test ◽  
P Value ◽  
Knee Oa ◽  
The Mean ◽  
Group B

INTRODUCTION: In Knee osteoarthritis (OA) Shoe modifications, such as lateral-wedge insoles or shock absorbing shoes with insoles, have been recommended for conservative therapy of mild knee OA but with little objective data on Indian patients. OBJECTIVE : this prospective study was done to study the effect of lateral heel sole wedging (insole) in the patients of OA of knee (medial compartment) and its relation to function,pain and stiffness parameters status on VAS and WOMAC scale and to see the requirement of the number of Aceclofenac tablets. METHODS: 60 patients fulfilling the inclusion criteria were enrolled and divided into intervention group A (30) and nonintervention Group B (30) with random allocation.Paired t-test,Wilcoxon sign rank test and Man Whitney U test were applied at significant p-value of <0.05%. RESULTS: the reduction of mean difference in pain on VAS and WOMAC scale, improvement in Mean difference in function parameters the mean reduction of pain in standing/ walking,bending and ascending/descending at WOMAC scale was significantly higher in intervention group. Also the mean reduction in the need for aceclofenac was significantly lower in intervention group evident from fourth week onward to fifth and sixth week.Conclusion:The lateral wedging in shoes in medial joint osteoarthritis is beneficial and it can be cost-effective conservative treatment modalities in early osteoarthritis patients, particularly in developing countries as it can reduces the requirement of NSAIDS and improve functional level of patients by reducing pain in various activities.

scholarly journals Comparative Effectiveness of Papaya Leaf Stew (Carica Papaya Linn) With Turmeric Acid (Curcuma Domestica Val-Tamarindus Indica) Against Primary Dysmenorrhea

2018 ◽  
Vol 1 (2) ◽  
pp. 120-127
Author(s):  
Yunita Liana
Keyword(s):  
Young Women ◽  
Rating Scale ◽  
Numeric Rating Scale ◽  
Average Score ◽  
Control Group ◽  
P Value ◽  
Primary Dysmenorrhea ◽  
Control Group Design ◽  
Before And After ◽  
The Mean

Young women often feel primary dysmenorrhoea because the hormonal cycles experienced are not stable, this can disrupt the concentration and activity of young women. The principle of back to nature is increasingly popular today, the side effects of chemical drugs can cause new problems, it is one of the driving force of the development of traditional medicine. Papaya leaves contain Vitamin E which can reduce dysmenorrhea. In addition, turmeric acids also contain curcumine and anthocyanins that inhibit cyclooxygenase, thereby reducing the occurrence of inflammation during uterine contractions. The aim of this research is to know the effectiveness of papaya leaf stew with acidic turmeric to primary dysmenorrhea. Type of Research is an experimental study with a Pretest-Posttest Control Group Design design. The sample is 30 people. The research was conducted on December 27, 2017 s.d February 24, 2018 at SMP Negeri 46 Palembang. Instrument to measure pain Numeric Rating Scale. The statistical test used by Wilcoxon and Mann Whitney U. Average score of pain before papaya leaves stem 5.40 ± 0.73 while the mean score of pain after given turmeric acid 5.33 ± 0.61 The mean score of pain after being given papaya leaves stew 3.60 ± 0.91 while the mean score of pain after given turmeric acid 4.06 ± 0.79. There was a difference of mean score of dysmenorrhea pain before and after given papaya leaf stem p value = 0.000. There is difference of mean score of dysmenorrhea pain before and after given turmeric acid p value = 0,002. There was no difference of mean score of dysmenorrhea pain before and after given papaya leaf sting and turmeric acid p value = 0,217. The decoction of papaya leaf and turmeric acid have the same effectiveness in reducing primary dysmenorrhea pain.

scholarly journals ShigellaBacteremia in a Patient with Visceral Leishmaniasis

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Mengistu Endris ◽  
Rezika Mohammed ◽  
Yegnasew Takele ◽  
Desalegn Woldeyohannes ◽  
Moges Tiruneh ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Blood Culture ◽  
Parasite Load ◽  
Treatment Center ◽  
High Grade ◽  
High Grade Fever ◽  
One Year ◽  
Underlying Diseases ◽  
Culture Negative ◽  
Hiv Negative

Bacteremia due toShigellais rare. A 26-year-old HIV-negative male presented with a persistent high-grade fever of two months duration to the Leishmaniasis Research and Treatment Center of University of Gondar Hospital. He was anorexic and had lost significant weight (from 76 to 57 kg in 4 months, BMI = 17.2 kg/m2). He also complained of headache, chills, and rigor. In the last one year, he was experiencing a few episodes of acute bloody diarrhea, the last episode being two months ago. Microscopy from splenic aspiration showed Leishman-Donovan bodies with parasite load of +3. The blood culture showedShigellaspecies, but the stool was culture negative. The isolate was sensitive to most tested antibiotic discs, sulfamethoxazole, ceftriaxone, gentamicin, tetracycline, and norfloxacilin, except ampicillin. Therefore, requesting blood culture for identifying unexpected type of organisms causing infections in patients with underlying diseases like visceral leishmaniasis should be encouraged.

Relative thrombocytosis following chemoradiation of patients with glioblastoma to predict survival.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e13527-e13527
Author(s):  
Keeratikarn Boonyawan ◽  
Jie Yang ◽  
Lihong Long ◽  
Qianghu Wang ◽  
Ravesanker Ezhilarasan ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Performance Status ◽  
Extent Of Resection ◽  
Potential Interaction ◽  
Rank Test ◽  
Poor Survival ◽  
Survival Difference ◽  
Before And After ◽  
The Mean ◽  
Complete Blood Counts

e13527 Background: Thrombocytosis is associated with poor survival in several malignancies and is both triggered by and promoting of tumor growth. We hypothesized that an increase in circulating platelets following standard temozolamide (TMZ) CRT and/or adjuvant TMZ would predict for decreased survival in patients with glioblastoma (GBM). Methods: We reviewed data of 122 patients with newly diagnosed, pathological-proven GBM from 2007 to 2016 with documented complete blood counts before the start of CRT, after CRT, before adjuvant TMZ, and after a minimum 2 cycles of adjuvant TMZ. The association between changes in blood count levels and patient survival was analyzed by log-rank test. Multivariate analysis was performed using known prognostic co-variates, including MGMT methylation, patient age, and performance status (PS). Results: The mean change in platelets before and after CRT was -46 k/µl (range -387 to 179 k/µl) and before and after adjuvant TMZ was -25 k/µl (range -408 to 143 k/µl). As a reference, the mean change in lymphocytes was -5.7 k/µl (range -0.7 to 1.3 k/µl) and -0.0 k/µl (range -1.6 to 0.9 k/µl) for CRT and adjuvant TMZ, respectively. Patients were dichotomized based on the relative change in platelets and lymphocytes from baseline (≤30% increase, “low”, n = 101 vs > 30% increase, “high”, n = 12). The median survival of low patients vs. high patients was 30 vs 13 months (p = 0.006). Potential confounders, such as infection or thrombosis, were not associated with the high group. However, no significant survival difference was observed between groups based on platelet changes during adjuvant TMZ. Similarly, changes in lymphocyte counts were not significantly prognostic. In multivariate analysis, extent of resection, MGMT status, PS and the increase in platelets after CRT were significantly associated with survival (HR for platelets 4.0, 95% CI 1.6-10.1). Conclusions: Increased platelet counts after CRT predict for poor survival in patients with GBM. The effect is platelet specific and does not reflect general bone marrow changes, as lymphocyte changes were not significantly prognostic. These results suggest a potential interaction between platelets and tumor aggressiveness.

scholarly journals PENGARUH PEMBERIAN MINUMAN KUNYIT ASAM TERHADAP INTENSITAS NYERI MENSTRUASI PADA REMAJA PUTRI

2020 ◽  
Vol 3 (1) ◽  
pp. 55-60
Author(s):  
Ika Nur Saputri ◽  
Dwi Handayani ◽  
Jurpia Yasara
Keyword(s):  
High School ◽  
Sample Selection ◽  
Rank Test ◽  
P Value ◽  
Acid Extract ◽  
Menstrual Pain ◽  
Natural Event ◽  
Before And After ◽  
Quasi Experimental ◽  
Wilcoxon Sign Rank

Menstruation is a natural and natural event, but in reality many women experience menstrual problems, including menstrual pain or dysmenorrhoea. Nonpharmacological menstrual pain management can be done by giving turmeric acid extract. This study aims to determine the effect of giving turmeric acid extract on the intensity of menstrual pain in adolescent girls in State High School 1 Serdang Bedagai Regency in 2020. The research method is quantitative. This type of research is a quasi-experimental design with one-group pretest-posttest design. The study population was 150 class X and XI students of State High School 1 Serdang Bedagai Regency as many as 150 people. The sample selection using purposive sampling as many as 36 people. The results of the study using Wilcoxon sign rank test showed p-value of 0,000 <0.05. The conclusion is there are differences before and after giving turmeric acid drink to the intensity of menstrual pain (dysmenorrhea). It is expected that schools can provide information to students about the use of turmeric acid as a non-pharmacological treatment in reducing menstrual pain.

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