scholarly journals INFLUENCE OF IMMUNIZATION WITH ANTI-INFLUENZA VACCINE ON THE COURSE AND OUTCOME OF COMMUNITY-ACQUIRED PNEUMONIA

Author(s):  
Светлана Нарышкина ◽  
Svetlana Naryshkina ◽  
Людмила Круглякова ◽  
Lyudmila Kruglyakova ◽  
Людмила Бугаева ◽  
...  

The community-acquired pneumonia (CAP) is a very widespread disease and one of frequent causes of death. The stable relation of seasonal dynamics of indicators of a case rate of CAP with incidence of acute respiratory viral infection and flu becomes perceptible. One of the modern trends of decreasing the incidence and mortality at CAP is immunization with anti-influenza vaccines. Flu immunizations are included in the National calendar of preventive immunization of the Russian Federation. According to official data of the Ministry of Health of the Amur region, in 2015, 2016 and 2017 there were vaccinated 39.7%, 45.4% and 46.2% of population, respectively. CAP case rate in the group immunized with anti-influenza vaccine and in the group not immunized were analyzed. The decrease of the case rate of CAP in patients immunized from flu by 2.4 times in comparison with the people who were not vaccinated from flu was revealed. Against the background of mass vaccination against flu there was a change of clinical implications of CAP: the number of people with mild forms of illness enlarged. Lethality decreased: from 179 immunized people only one patient died, whereas from 393 not immunized people 28 patients had a lethal outcome. The case rate of CAP in people of the senior age groups decreased from 32.2% in 2009-2014 till 21.7% in 2015, from 17.8% in 2016 till 15.9% in 2017. Thus, immunization against flu is followed by an essential decrease of indicators of a case rate of CAP, relief of a disease and improvement of a disease outcome.

Author(s):  
Alla Nikolaevna Kaira ◽  
Oksana Anatolievna Svitich ◽  
Alena Andreevna Murzina

The review of available literature sources and Internet resources for 2019–2021 is presented. It is devoted to the age-gender characteristics of the incidence of COVID-19, as well as mortality and mortality as a result of coronavirus infection in the world and in the Russian Federation as of May 2021. It is established that the main number of cases of new coronavirus infection is concentrated among the young working population from 40 to 59 years. At the same time, some countries have their own characteristics with a shift to younger age groups. There were no significant differences between men and women, with the exception of the age group of 85 years and older, where the female population prevails. The analysis of lethality showed that the most vulnerable groups are those over 80 years of age.


2020 ◽  
Vol 76 (4) ◽  
pp. 30-36
Author(s):  
S.K. Udovichenko ◽  
◽  
K.V. Zhukov ◽  
D.N. Nikitin ◽  
A.V. Toporkov ◽  
...  

An assessment of the manifestations of the COVID-19 epidemic process in the Volgograd region in terms of intensity, territorial distribution, structure, and clinical patterns of the disease was carried out. The study used the official data of the Rospotrebnadzor Office in the Volgograd region. From March 24 to October 18, 2020, 17 811 cases of COVID-19 were registered in the region, the incidence rate was 715 per 100 thousand of the population, the case fatality rate was 0,98 %. An uneven distribution of morbidity over the territory was established: 42,3 % of cases were detected in Volgograd, 10,1% in Volzhsky and 6 % in Kamyshinsky district. The age groups 40–49 years old (17,6 %) and 50–59 years old (19,2 %) are most involved in the epidemic process. In the cases structure, the prevalence of females was noted (58,3 %). The clinical patterns of the disease are characterized by the predominance of mild forms (46,8 %), there is a trend to reduce asymptomatic forms and an increase in moderate manifestations. In the Volgograd region, a lower frequency of severe forms and deaths registration has been established in comparison with the Russian Federation. In the social structure of the infected people, the largest share is made up of pensioners (26,3 %) and workers (16,9 %)


Author(s):  
Rimma N. Terletskaya ◽  
Ludmila M. Kuzenkova ◽  
Irina V. Vinyarskaya ◽  
Anna N. Lashkova

Introduction. Knowledge of the prevalence of autism in children is a prerequisite for the organization of medical and social care for this population of patients. Aim: to determine the prevalence of autism among the children of the Russian Federation of different age groups according to official statistics. Materials and methods. An analysis of official data on the incidence and prevalence of disability in autism in children of different age groups (0-4 years, 5-9, 10-14 and 15-17 years) for the period 2016-2018 was carried out. The share of autism in the structure of morbidity and disability caused by mental disorders and behavioral disorders was determined. Results. There has been an increase in cases of autism diagnosis among the child population, extremely significant among adolescents aged 15-17. The age structure of autism cases has changed - the proportion of children aged 0-4, 5-9 and the proportion of adolescents aged 15-17 has significantly decreased. The prevalence of autism-related disability compared to morbidity has not increased as significantly. Its highest rates were among children aged 5-9. Due to the sharp increase in autism cases, the proportion of persons with disabilities among them has decreased several times. The incidence of autism in the structure of morbidity and disability caused by mental disorders and behavioral disorders in children aged 0-17 has increased. Conclusion. The obtained data can be used in the organization of medical and social care for children suffering from autism. The need for special epidemiological studies to determine the true prevalence of autism in children seems relevant.


Dermatology ◽  
2020 ◽  
Vol 236 (6) ◽  
pp. 500-507
Author(s):  
Anastasiya Muntyanu ◽  
Evgeny Savin ◽  
Feras M. Ghazawi ◽  
Akram Alakel ◽  
Andrei Zubarev ◽  
...  

<b><i>Background:</i></b> Cutaneous melanoma (CM) incidence has been increasing around the world. The goal of this study is to describe geographic trends in incidence and mortality of CM in Russia between 2001 and 2017. <b><i>Methods:</i></b> To achieve this we used geo-informatic technique (mapping) and descriptive statistical analysis. Additionally, we studied the associations between ethnicity, geographic latitude/longitude, and CM incidence/mortality rates. We retrospectively analyzed the data from the Moscow Oncology Research Institute, Ministry of Health of the Russian Federation, for the period of the study. Routine methods of descriptive epidemiology were used to study incidence and mortality rates by age groups, years, and jurisdictions (i.e., Federal Districts and Federal Subjects of Russia). <b><i>Results:</i></b> In total, 141,597 patients were diagnosed with melanoma in Russia over the period 2001–2017, of whom 62% were women. The overall age-standardized incidence and mortality rates were 4.27/100,000 and 1.62/100,000, respectively. Geographic mapping revealed north-to-south and east-to-west gradients. As the study was fully descriptive, retrospective, and based on official statistical reports, detailed characteristics of clinical forms, anatomic sites, Breslow depth, and treatments could not be analyzed. <b><i>Conclusions:</i></b> This study outlined the burden of melanoma in the Russian Federation, and the trends were similar to those observed in countries with similar latitudes and skin phenotype. The importance of the skin color gradient and recreational/cultural practices were some of the most important risk factors highlighted in this study for the development of melanoma in Russia.


2020 ◽  
Vol 3 (6) ◽  
pp. 8-11
Author(s):  
Bakaev Zh. N.

According to the authors, the prevalence of SOPR diseases is from 3 to 20%.In a study of 1573 residents of southern China in two age groups who use tobacco and alcohol, the incidence of SOPR was higher among men living in rural areas compared to urban residents. Among women aged 35-44 years, the incidence was higher in urban women, and in the 65-77-year-old group in rural women. In the course of studies in Brazil, among 335 patients older than 60 years, 646 diseases of the SOPR were identified. Similar results were obtained in the analysis of SOPR diseases in the Volgograd region of the Russian Federation


Author(s):  
Timur Minasov ◽  
Radik Nurlygayanov ◽  
Angela Vershinina ◽  
Yulia Soboleva ◽  
Damir Akhmeldinov ◽  
...  

The results of a study of the concentration of vitamin D in blood serum of 3455 residents of Ufa are presented. Physiological values of 25(OH)D were observed in 34.9 % (274) of men and 31.7 % (847) of women, which is 32.4 % (1121) of all examined. Vitamin D deficiency was detected in 67.1 % of the examined. The level of 25(OH)D in the blood serum of residents is on average 75 nmol/L, which is the upper limit of vitamin D deficiency. Vitamin D deficiency is extremely common among residents of this region of the Russian Federation (67.1 %).


Medicina ◽  
2021 ◽  
Vol 57 (7) ◽  
pp. 665
Author(s):  
Miodrag M. Stojanovic ◽  
Natasa K. Rancic ◽  
Marija R. Andjelkovic Apostolovic ◽  
Aleksandra M. Ignjatovic ◽  
Mirko V. Ilic

Somach cancer is the third most common cause of cancer-related deaths worldwide. The objective of the paper was to analyze the incidence and mortality trends of stomach cancer in Central Serbia in the period between 1999–2017. Materials and Methods: trends and annual percentage change (APC) of the incidence and mortality rate with corresponding 95% confidence intervals (CI) were calculated by joinpoint regression analyses. The optimal number of Joinpoints was identified using the Monte Carlo permutation method. The trend was considered to be significantly increasing (positive change) or decreasing (negative change) when the p-value was below 0.05 (p < 0.05). Results: the total number of new cases was 16,914 (10,873 males and 6041 females) and the total number of mortality cases was 14,790 (9348 in and 5442 in females). Almost one third (30.8%) of new cases were registered in the 60–69-year age group, and new cases were significantly more frequent in males than in females (30.8% vs. 29.02%, p < 0.001). Joinpoint regression analysis showed a significant decrease of incidence trend in females during the 2000–2015 period with APC of −2.13% (95% CI: −3.8 to −0.5, p < 0.001). An insignificant decrease in incidence trend was in males with APC of −0.72% (95% CI: −2.3 to 0.9, p = 0.30). According to the joinpoint analysis, a significant decrease of mortality trends both in males during 2000–2015 with APC of −2.21% (95% CI: −1.6 to −7.5, p ≤ 0.001 and in females, during the same period, with APC of −1.75% (95% CI: −2.9 to −0.6, p < 0.001) was registered. From 2015 to 2017, a significant increase of mortality was registered with APC of 44.5% (95% CI: from 24.2 to −68.1, p ≤ 0.001) in females and in males with APC of 53.15% (95% CI: 13.5 to −106.6, p ≤ 0.001). Conclusion: a significant decrease of stomach cancer incidence trend in females and insignificant decrease of incidence trend in males were determined in Central Serbia. Based on presented results, the mortality trend decreased significantly both in males and in females during 2000–2015, and from 2015 to 2017 we recorded a significant increase in mortality in both sexes. We found significantly more new cases in women than in men in the age group of 40–49, and the mortality of stomach cancer was significantly more frequent among females compared to males in the age groups 30–39, as well as in the 50–59 age group. There is a need for improving recording and registration of new cases of stomach cancer, especially in females. Urgent primary and secondary preventive measures are needed—introducing stomach cancer screening and early detection of premalignant changes. Urgent primary and secondary preventive measures are needed.


2008 ◽  
Vol 61 (1-2) ◽  
pp. 16-21 ◽  
Author(s):  
Natasa Maksimovic ◽  
Kyriakos Spanopoulos

Introduction. Lung cancer represents the most common malignant tumour among men, and appears more and more frequently among women in many countries worldwide. The aims of this descriptive epidemiological study were to evaluate the mortality trends of all malignant tumours and lung cancer in Central Serbia from 1990 to 1999, and to estimate the incidence, mortality and the basic demographic characteristics of lung cancer in Central Serbia in 1999. Material and methods. The source of data concerning cancer cases in 1999 was the Cancer Registry of Central Serbia, while data of the Republic Statistics Institute were used for the analysis of mortality trends for the period 1990-1999. All rates were standardized by the direct method, to the world standard population. Confidence intervals for mortality rates were assessed with 95% level of probability. Linear regression coefficient was determined by Fisher's test. Results. The mortality rates showed rising tendencies for both lung cancer (y=-1876.26+0.96x, p=0.028 for men; y=654.78U).33x, p-0.001 for women) and all malignant tumours (y=-4139.88+2.15x, p=0.163 for men; y=3649.68 + 1.88x, p=0.016 for women), with statistically significant increase being observed for all trends, except all malignant tumours among men. In the year 1999, lung cancer ranked first among men and third among women, with 29.2% and 10.3% of cancer mortality respectively. The age-specific mortality rates were much higher in men in all age groups. Mortality increased with age and the highest rates were found in the age group 70-74 for both sexes. The highest incidence and mortality rates were reported in Belgrade, Moravicki and Sumadijski district. .


Author(s):  
Carina Musetti ◽  
Mariela Garau ◽  
Rafael Alonso ◽  
Marion Piñeros ◽  
Isabelle Soerjomataram ◽  
...  

Uruguay has the highest colorectal cancer incidence rates in Latin America. Previous studies reported a stable incidence and a slight increase in mortality among males. We aimed to assess colorectal cancer incidence (2002–2017) and mortality trends (1990–2017) by age groups and sex, using data from the National Cancer Registry. Annual percent changes (APCs) were estimated using joinpoint regression models. We included 27,561 colorectal cancer cases and 25,403 deaths. We found an increasing incidence among both males and females aged 40–49, with annual increases of 3.1% (95%CI: 1.21–5.03) and 2.1% (95%CI: 0.49–3.66), respectively, and an increasein the rate in older males (70+) of 0.60% (95%CI: 0.02–1.20) per year between 2002 and 2017. Mortality remained stable among those younger than 50, whereas it decreased for older females aged 50–69 and 70+ (APC: −0.61% (−1.07–0.14) and −0.68% (−1.02–0.34), respectively), and increased for the oldest males (70+; APC: 0.74 (0.47–1.01)). In conclusion, we found rising colorectal cancer incidence accompanied by stable mortality in young adults. Sex disparities were also found among the older adults, with a more favorable pattern for females. Exposures to dietary and lifestyle risk factors, and inequalities in access to and awareness of screening programs, are probably among the main underlying causes and deserve further investigation.


Author(s):  
Е.Е. Краснова ◽  
В.В. Чемоданов ◽  
Е.Г. Кузнецова

Пневмония – острое инфекционно-воспалительное заболевание легких преимущественно бактериальной этиологии, характеризующееся выраженной в разной степени дыхательной недостаточностью, токсическими и респираторными нарушениями, локальными физикальными симптомами, а также инфильтративными изменениями на рентгенограмме. Заболеваемость внебольничными пневмониями повышается в октябре-декабре, достигая максимума в январе-апреле, коррелируя с сезонным повышением уровня острых респираторных вирусных инфекций. Схожесть симптомов дебюта пневмонии с проявлениями острых респираторных вирусных инфекций может привести к несвоевременной ее диагностике и, как следствие, к отсроченному началу лечения. Поэтому в период сезонной заболеваемости респираторными инфекциями должна повышаться настороженность врачей-педиатров в отношении внебольничной пневмонии. Антибактериальная терапия оказывает решающее влияние на прогноз пневмонии, поэтому при достоверном диагнозе или у больного в тяжелом состоянии с вероятным диагнозом ее следует начать незамедлительно. Выбор антибиотика в каждом случае внебольничной пневмонии проводят индивидуально с учетом природной активности препаратов в отношении предполагаемого возбудителя и их возможной приобретенной резистентности, тяжести и течения заболевания, наличия у пациента противопоказаний к использованию тех или иных антибиотиков. В статье приводятся сведения о диагностических критериях внебольничных пневмоний. Рассмотрены вопросы антибактериального лечения типичной нетяжелой пневмонии у детей разных возрастных групп амоксициллином с клавулановой кислотой и показана его эффективность. Результаты проведенного исследования позволяют заключить, что пероральное использование одного курса защищенного аминопенициллина эффективно при лечении типичной внебольничной нетяжелой пневмонии у детей разного возраста, о чем свидетельствует ликвидация основных клинических проявлений болезни в короткие сроки. Pneumonia is an acute infectious and inflammatory lung disease of predominantly bacterial etiology, characterized by respiratory failure, toxic and respiratory disorders, local physical symptoms, and infiltrative changes on the roentgenogram. The incidence of community-acquired pneumonia increases in October-December, reaching a maximum in January-April, correlating with the seasonal increase in the level of acute respiratory viral infections. The similarity of the symptoms of the onset of pneumonia with the manifestations of acute respiratory viral infections can lead to its untimely diagnosis and, as a consequence, to a delayed start of treatment. Therefore, during the period of seasonal morbidity with respiratory infections, the alertness of pediatricians in relation to community-acquired pneumonia should increase. Antibiotic therapy has a decisive influence on the prognosis of pneumonia, therefore, with a reliable diagnosis or in a patient in serious condition with a probable diagnosis, it should be started immediately. The choice of antibiotic in each case of community-acquired pneumonia is carried out individually, taking into account the natural activity of the drugs in relation to the alleged pathogen and their possible acquired resistance, the severity and course of the disease, the patient's contraindications to the use of certain antibiotics. The article provides information on the diagnostic criteria for community-acquired pneumonia. The issues of antibacterial treatment of typical non-severe pneumonia in children of different age groups with amoxicillin with clavulanic acid are considered and its effectiveness is shown. The results of the study allow us to conclude that the oral use of one course of protected aminopenicillin is effective in the treatment of typical community-acquired non-severe pneumonia in children of different ages, as evidenced by the elimination of the main clinical manifestations of the disease in a short time.


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