Nutrition to Prevent or Treat Cognitive Impairment in Older Adults: A GRADE Recommendation

2020 ◽  
pp. 1-7
Author(s):  
F. Buckinx ◽  
M. Aubertin-Leheudre
Keyword(s):  
Fatty Acids ◽  
Fruits And Vegetables ◽  
Unsaturated Fatty Acids ◽  
Cognitive Impairments ◽  
Meta Analysis ◽  
Saturated Fatty Acids ◽  
Dietary Factors ◽  
Modifiable Factor ◽  
High Level ◽  
Low Consumption

Aging is associated with cognitive declines leading to mild cognitive impairments or Alzheimer disease. Nutrition appear to protect from aging. Some dietary factors could either increase or protect against cognitive declines. This article aimed to provide GRADE recommendations related to nutrition aspects able to prevent or to treat cognitive impairments. A comprehensive literature review was performed using Medline database. The GRADE approach was used to classify quality of the existing evidence (systematic review or meta-analysis).The GRADE process led us to formulate seven key nutritional recommendations to manage cognitive declines, but did not allow us to do it for protein, vitamin B or antioxidants. Thus, 1) adherence to a Mediterranean diet (GRADE 1B); 2) high-level of consumption of mono- or poly- unsaturated fatty acids combined to a low consumption of saturated fatty acids (GRADE 1B); 3) high consumption of fruits and vegetables (GRADE 1B); 4) higher vitamin D intake (GRADE 1C) than the recommended daily allowance. In addition, a ketogenic diet, a low consumption of whole-fat dairy products or a caloric restriction are promising nutritional habits although the evidence does not yet support widespread uptake (GRADE 2C). In conclusion, nutrition is an important modifiable factor to prevent or protect against cognitive decline. Nevertheless, more studies are required to determine specific guidelines such as duration and amounts of nutrients to help older adult to maintain a healthy cognitive life.

Abstract MP068: Dietary Fatty Acids and Coronary Heart Disease in Mortality in the Alpha Omega Cohort

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Famke J Mölenberg ◽  
Janette de Goede ◽  
Anne J Wanders ◽  
Peter L Zock ◽  
Daan Kromhout ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lower Risk ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Dietary Cholesterol ◽  
Dietary Factors ◽  
Dietary Fatty Acids ◽  
Alpha Omega

Background: Replacement of saturated fatty acids (SFA) with polyunsaturated fatty acids (PUFA) is associated with a lower risk of coronary heart disease (CHD) in the general population. Whether this is also the case for CHD patients is not yet clear. In this observational study of Dutch CHD patients, we examined the risk of CHD mortality for the exchange of SFA with total unsaturated fatty acids (UFA), PUFA and cis -monounsaturated fatty acids (MUFA). Methods: We included 4146 post-myocardial infarction patients aged 60-80 (78% male; Alpha Omega Cohort) in whom diet was assessed at baseline (2002-2006) by a validated 203-item food-frequency questionnaire. Cause-specific mortality was monitored until January 2013. Iso-caloric replacement of SFA with (subgroups of) UFA in relation to CHD mortality was studied in quintiles and continuously per 5 energy percent (en%), using Cox regression models. Hazard ratios (HR, 95%-CI) were obtained after adjustment for age, sex, BMI, smoking, education, physical activity, cardiovascular drugs (anticoagulants, antihypertensives, statins), diabetes, and dietary factors, i.e. total energy, protein (en%), carbohydrates (en%), trans fatty acids (en%), dietary fiber (g/d) and dietary cholesterol (mg/d). The model for PUFA also included MUFA as a covariate, and vice versa . Results: During a median follow-up of 7.3 years, there were 888 deaths including 249 CHD deaths. SFA replacement was inversely associated with CHD mortality when comparing extreme quintiles of intake, which was statistically significant for total UFA (HR: 0.44; 95% CI: 0.21-0.92; P = 0.03) and non-significant for PUFA (0.58, 0.31-1.09) and MUFA (0.81, 0.45-1.49). When expressed per 5 en% (Figure), replacing SFA with either UFA, PUFA or MUFA was associated with a more than 30% lower risk of CHD mortality. Findings were similar when confined to statin users. Conclusion: In well-treated CHD patients, replacement of SFA by UFA is associated with a lower CHD mortality risk.

scholarly journals Clinical Outcomes of Dietary Replacement of Saturated Fatty Acids with Unsaturated Fat Sources in Adults with Overweight and Obesity: A Systematic Review and Meta-Analysis of Randomized Control Trials

2017 ◽  
Vol 71 (1-2) ◽  
pp. 107-117 ◽  
Author(s):  
Bridget A. Hannon ◽  
Sharon V. Thompson ◽  
Ruopeng An ◽  
Margarita Teran-Garcia
Keyword(s):  
Systematic Review ◽  
Fatty Acids ◽  
Body Composition ◽  
Unsaturated Fatty Acids ◽  
Keyword Search ◽  
Meta Analysis ◽  
Saturated Fatty Acids ◽  
Overweight And Obesity ◽  
Cochrane Library ◽  
Unsaturated Fat

Background: Obesity and dyslipidemia are frequently treated with dietary interventions before pharmacotherapy is given. Diets high in unsaturated fat have proven advantageous to disease treatment. Aims: The purpose of this systematic review and meta-analysis was to assess the evidence of the effect of saturated fatty acids (SFA) replacement with unsaturated fatty acids (UFA) in metabolically healthy adults with overweight and obesity on markers of dyslipidemia and body composition. Methods: Keyword search was performed in PubMed, CINAHL, and Cochrane Library for randomized controlled trials (RCTs) evaluating the effects of fatty acid substitution in adults with overweight and obesity. Meta-analysis was performed on interventions assessing lipoprotein levels and body composition. Publication bias was assessed by funnel plot inspection, Begg's, and Egger's test. Results: Eight RCTs enrolling 663 participants were included in the review, with intervention durations between 4 and 28 weeks. Although nonsignificant (p = 0.06), meta-analysis found UFA replacement to reduce total cholesterol concentrations by 10.68 mg/dL (95%CI -21.90 to 0.53). Reductions in low-density lipoprotein cholesterol and triglycerides were statistically nonsignificant. Conclusions: Due to null results and a small number of studies included, there is no strong evidence that replacement of SFA with UFA may benefit lipid profiles in this population.

scholarly journals Vegetable and fruit consumption associated with anthropometric, dietary and lifestyle factors in Spain

1999 ◽  
Vol 2 (3) ◽  
pp. 263-271 ◽  
Author(s):  
Antonio Agudo ◽  
Guillem Pera ◽  
Keyword(s):  
Physical Activity ◽  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Vegetable Intake ◽  
Saturated Fatty Acids ◽  
Dietary Factors ◽  
Fruit Intake ◽  
Cross Sectional ◽  
Lineal Regression ◽  
Sectional Analysis

AbstractObjectiveTo evaluate the association of vegetable and fruit intake with several demographic, anthropometric, lifestyle and dietary factors.Design and settingCross-sectional analysis. Information on habitual diet was collected by means of the diet history method. Association of vegetable and fruit intakes with other factors was assessed separately by means of multiple lineal regression and the cumulative odds model.Subjects39 622 healthy subjects aged 29–69 years from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort in Spain.ResultsFruit intake increased with age, education and physical activity and decreased with intake of saturated fatty acids and cholesterol; smoking and alcohol consumption were also negatively associated with fruit, with a very low consumption for current smokers and heavy drinkers. Vegetable intake increased with education and physical activity and with intake of unsaturated fatty acids, mainly mono-unsaturated. Former smokers consumed more vegetables than never or current smokers and non-consumers of alcohol ate less vegetables than consumers, among whom no differences were observed. All these estimates were adjusted by energy and body mass index (BMI).ConclusionsWhen assessing the association of fruit and vegetables with chronic diseases it is important to take into account confounding factors. Furthermore, it would be useful to study dietary patterns including several interrelated factors.

scholarly journals Model Experiment Analysis of the Antioxidant Effect of Conjugated Linoleic Acid

2007 ◽  
pp. 15-18
Author(s):  
Anikó Borosné Győri ◽  
Rozália Salamon ◽  
János Gundel ◽  
Zoltán Győri ◽  
Szidónia Salamon ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Acid Number ◽  
Antioxidant Effect ◽  
Peroxide Number ◽  
Long Period ◽  
High Level

Corn milled like flour was crumbled with 5% butter containing a high level of conjugated linoleic acid, then kept exposed to air on an aluminium tray at a layer of 1 cm thickness. Its acid number, peroxide number and fatty acid composition were measured weekly. It was established that during a 24 week long period, there was very little change in the composition of fatty acids, but after this, in parallel with the increasing acid number and peroxide number, the amount of unsaturated fatty acids decreased, while those values for saturated fatty acids did not change considerably. With these investigations, the authors proved the antioxidant effect of conjugated linoleic acid.

scholarly journals Dietary intake of fatty acids and risk of pancreatic cancer: Golestan cohort study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Neda Ghamarzad Shishavan ◽  
Sahar Masoudi ◽  
Ashraf Mohamadkhani ◽  
Sadaf G. Sepanlou ◽  
Maryam Sharafkhah ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Fatty Acids ◽  
Cohort Study ◽  
Dietary Intake ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Cox Proportional Hazards ◽  
Dietary Factors ◽  
Dietary Intakes ◽  
Increased Risk

Abstract Background As pancreatic cancer (PC) is a malignancy with poor prognosis, finding strategies for its prevention became a notable priority. Among all the factors influencing the risk of PC, dietary items especially fats are considered as the most modifiable risk factors.This study is designed to assess the associations of dietary intake of fatty acids with the risk of PC incidence. Methods A total of 50,045 adults between 40 and 75 years old participated in this cohort study in 2004–2008 and were followed up to the present. Intakes of fatty acids was evaluated by validated food-frequency questionnaire (FFQ). Cox proportional hazards regression model was used to estimate hazard ratio (HR) with 95 % confidence interval of differing levels of dietary intakes of fatty acids for incidence of PC. Results At the end of follow-up period, 76 cases of PC were identified and 46,904 participants without history of cancer, acute kidney disorders, fibrosis and cirrhosis were included in the study. Dietary total saturated fatty acids (SFAS) was associated with PC risk (HR = 1.05 (1.01–1.09), Ptrend=0.01), whereas dietary total monounsaturated fatty acids (MUFAS) was inversely associated with the risk of PC (HR = 0.92 (0.86–0.99), Ptrend=0.04). Dietary total polyunsaturated fatty acids (PUFAS) did show a protective but not significant association with the risk of PC (HR = 0.91(0.84-1.00), Ptrend=0.05). Conclusions The amount of total fat intake is not a risk factor for PC in our study and focusing on the intake of specific fatty acids becomes more striking. Unsaturated fatty acids including PUFAS and especially MUFAS are considered as protective dietary factors in PC prevention. In contrast, total SFAS is positively associated with the increased risk of PC. However, very long chain and odd-chain saturated fatty acids intake may be protective against PC.

scholarly journals CHARACTERIZATION OF GENE KETOACYL-ACP SYNTHASE II (KAS II) β ON Elaeis guineensis, Elaeis oleifera, AND INTERSPECIFIC HYBRID

2016 ◽  
Vol 24 (3) ◽  
pp. 127-142
Author(s):  
Heri Adriwan Siregar ◽  
Sri Wening ◽  
Abdul Razak Purba
Keyword(s):  
Fatty Acids ◽  
Oil Palm ◽  
Unsaturated Fatty Acids ◽  
Elaeis Guineensis ◽  
Saturated Fatty Acids ◽  
Species Difference ◽  
Gene Encoding ◽  
Elaeis Oleifera ◽  
Lower Productivity ◽  
High Level

Oil palm (Elaeis guineensis) is currently the highest edible oil-producing plant in the world. E. oleifera is another species of oil palm that is not widely cultivated due to lower productivity. Oil extracted from E. guineensis has a balance ratio of saturated to unsaturated fatty acids level, while E. oleifera has a higher unsaturated fatty acids. Long chain saturated fatty acids are more harmful for human health than unsaturated fatty acids. Gene encoding β-ketoacyl ACP synthase II (KAS II, EC 2.3.1.179) was studied, as this enzyme is responsible for biosynthesis of unsaturated fatty acids. Observation and analysis were conducted for KAS II gene and fatty acids content of E. guineensis represented by DxP Lame, DxP Langkat and CMR78 samples, E. oleifera represented by Suriname origin, and two hybrids (E. guineensis x E. oleifera (Brazil and Suriname)). The results showed E. oleifera Suriname had the highest concentration of oleic acid, followed by E. guineensis (CMR78). KAS II gene sequences alignment showed some genetic variation within E. guineensis and hybrids, while the high level of variation found between E. guineensis and E. oleifera was considered caused by species difference.

scholarly journals Association of Adherence to a Healthy Diet with Cognitive Decline in European and American Older Adults: A Meta-Analysis within the CHANCES Consortium

2017 ◽  
Vol 43 (3-4) ◽  
pp. 215-227 ◽  
Author(s):  
Agnes A.M. Berendsen ◽  
Jae H. Kang ◽  
Ondine van de Rest ◽  
Nicole Jankovic ◽  
Ellen Kampman ◽  
...  
Keyword(s):  
Older Adults ◽  
Fatty Acids ◽  
Cognitive Decline ◽  
Repeated Measures ◽  
Fruits And Vegetables ◽  
Meta Analysis ◽  
Saturated Fatty Acids ◽  
Cognitive Status ◽  
Healthy Diet ◽  
Health Study

Aim: To examine the association between a healthy diet, assessed by the Healthy Diet Indicator (HDI), and cognitive decline in older adults. Methods: Data from 21,837 participants aged ≥55 years from 3 cohorts (Survey in Europe on Nutrition and the Elderly, a Concerted Action [SENECA], Rotterdam Study [RS], Nurses' Health Study [NHS]) were analyzed. HDI scores were based on intakes of saturated fatty acids, polyunsaturated fatty acids, mono- and disaccharides, protein, cholesterol, fruits and vegetables, and fiber. The Telephone Interview for Cognitive Status in NHS and Mini-Mental State Examination in RS and SENECA were used to assess cognitive function from multiple repeated measures. Using multivariable-adjusted, mixed linear regression, mean differences in annual rates of cognitive decline by HDI quintiles were estimated. Results: Multivariable-adjusted differences in rates in the highest versus the lowest HDI quintile were 0.01 (95% CI -0.01, 0.02) in NHS, 0.00 (95% CI -0.02, 0.01) in RS, and 0.00 (95% CI -0.05, 0.05) in SENECA with a pooled estimate of 0.00 (95% CI -0.01, 0.01), I2 = 0%. Conclusions: A higher HDI score was not related to reduced rates of cognitive decline in European and American older adults.

CHARACTERIZATION OF GENE KETOACYL-ACP SYNTHASE II (KAS II) β ON Elaeis guineensis, Elaeis oleifera, AND INTERSPECIFIC HYBRID

2018 ◽  
Vol 24 (3) ◽  
pp. 127-142
Author(s):  
Heri Adriwan Siregar ◽  
Sri Wening ◽  
Abdul Razak Purba
Keyword(s):  
Fatty Acids ◽  
Oil Palm ◽  
Unsaturated Fatty Acids ◽  
Elaeis Guineensis ◽  
Saturated Fatty Acids ◽  
Species Difference ◽  
Gene Encoding ◽  
Elaeis Oleifera ◽  
Lower Productivity ◽  
High Level

Oil palm (Elaeis guineensis) is currently the highest edible oil-producing plant in the world. E. oleifera is another species of oil palm that is not widely cultivated due to lower productivity. Oil extracted from E. guineensis has a balance ratio of saturated to unsaturated fatty acids level, while E. oleifera has a higher unsaturated fatty acids. Long chain saturated fatty acids are more harmful for human health than unsaturated fatty acids. Gene encoding β-ketoacyl ACP synthase II (KAS II, EC 2.3.1.179) was studied, as this enzyme is responsible for biosynthesis of unsaturated fatty acids. Observation and analysis were conducted for KAS II gene and fatty acids content of E. guineensis represented by DxP Lame, DxP Langkat and CMR78 samples, E. oleifera represented by Suriname origin, and two hybrids (E. guineensis x E. oleifera (Brazil and Suriname)). The results showed E. oleifera Suriname had the highest concentration of oleic acid, followed by E. guineensis (CMR78). KAS II gene sequences alignment showed some genetic variation within E. guineensis and hybrids, while the high level of variation found between E. guineensis and E. oleifera was considered caused by species difference.

DEVELOPMENT OF AN EXPERIMENTAL MODEL OF AVITAMINOSIS F

2020 ◽  
Vol 20 (2) ◽  
pp. 38-40
Author(s):  
A. Levitsky ◽  
A. Lapinska ◽  
I. Selivanskaya
Keyword(s):  
Fatty Acids ◽  
Experimental Model ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Coconut Oil ◽  
The Body ◽  
Regulatory Function ◽  
Omega 3 ◽  
White Rats ◽  
Arachidonic Acids

The article analyzes the role of essential polyunsaturated fatty acids (PUFA), especially omega-3 series in humans and animals. The biosynthesis of essential PUFA in humans and animals is very limited, so they must be consumed with food (feed). Тhe ratio of omega-3 and omega-6 PUFA is very important. Biomembranes of animal cells contain about 30% PUFA with a ratio of ω-6/ ω-3 1-2. As this ratio increases, the physicochemical properties of biomembranes and the functional activity of their receptors change. The regulatory function of essential PUFA is that in the body under the action of oxygenase enzymes (cyclooxygenase, lipoxygenase) are formed extremely active hormone-like substances (eicosanoids and docosanoids), which affect a number of physiological processes: inflammation, immunity, metabolism. Moreover, ω-6 PUFA form eicosanoids, which have pro-inflammatory, immunosuppressive properties, and ω-3 PUFAs form eicosanoids and docosanoids, which have anti-inflammatory and immunostimulatory properties. Deficiency of essential PUFA, and especially ω-3 PUFA, leads to impaired development of the body and its state of health, which are manifestations of avitaminosis F. Prevention and treatment of avitaminosis F is carried out with drugs that contain PUFA. To create new, more effective vitamin F preparations, it is necessary to reproduce the model of vitamin F deficiency. An experimental model of vitamin F deficiency in white rats kept on a fat –free diet with the addition of coconut oil, which is almost completely free of unsaturated fatty acids, and saturated fatty acids make up almost 99 % of all fatty acids was developed. The total content of ω-6 PUFA (sum of linoleic and arachidonic acids), the content of ω-3 PUFA (α-linolenic, eicosapentaenoic and docosahexaenoic acids) in neutral lipids (triglycerides and cholesterol esters) defined. Тhe content of ω-6 PUFA under the influence of coconut oil decreased by 3.3 times, and the content of ω-3 PUFA - by 7.5 times. Тhe influence of coconut oil, the content of ω-6 PUFA decreased by 2.1 times, and the content of ω-3 PUFA - by 2.8 times. The most strongly reduces the content of ω-3 PUFA, namely eicosapentaenoic, coconut oil, starting from 5 %. Consumption of FFD with a content of 15 % coconut oil reduces the content of eicosapentaenoic acid to zero, ie we have an absolute deficiency of one of the most important essential PUFAs, which determined the presence of vitamin F deficiency.

EFFECT OF GINGER, LEMURU FISH OIL SAPONIFICATION AND OLIVE OIL ON COMPOSITION FATTY ACID OF BEEF

2014 ◽  
Vol 4 (1) ◽  
pp. 31-39
Author(s):  
Siwitri Kadarsih
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fish Oil ◽  
Olive Oil ◽  
Rice Bran ◽  
Dry Matter ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Omega 3 ◽  
Omega 6

The objective was to get beef that contain unsaturated fatty acids (especially omega 3 and 6), so as to improve intelligence, physical health for those who consume. The study design using CRD with 3 treatments, each treatment used 4 Bali cattle aged approximately 1.5 years. Observations were made 8 weeks. Pasta mixed with ginger provided konsentrat. P1 (control); P2 (6% saponification lemuru fish oil, olive oil 1%; rice bran: 37.30%; corn: 62.70%; KLK: 7%, ginger paste: 100 g); P3 (lemuru fish oil saponification 8%, 2% olive oil; rice bran; 37.30; corn: 62.70%; KLK: 7%, ginger paste: 200 g). Konsentrat given in the morning as much as 1% of the weight of the cattle based on dry matter, while the grass given a minimum of 10% of the weight of livestock observation variables include: fatty acid composition of meat. Data the analyzies qualitative. The results of the study showed that the composition of saturated fatty acids in meat decreased and an increase in unsaturated fatty acids, namely linoleic acid (omega 6) and linolenic acid (omega 3), and deikosapenta deikosaheksa acid.Keywords : 

Sign in / Sign up

Export Citation Format

Share Document