scholarly journals ЕФЕКТИВНІСТЬ ДОБАВКИ «СИЛІМАСК» ЗА ЕКСПЕРИМЕНТАЛЬНОГО ТОКСИКОЗУ У ЩУРІВ

2016 ◽  
Vol 18 (3(71)) ◽  
pp. 25-29
Author(s):  
O. Zhuravlоv ◽  
V. Hunchak
Keyword(s):  
Alkaline Phosphatase ◽  
Functional State ◽  
Biologically Active ◽  
System Level ◽  
Milk Thistle ◽  
Serum Total Protein ◽  
Digital Measurements ◽  
External Stimuli ◽  
The Impact ◽  
Positive Effect

Chronic experimental poisoning of rats by carbon tetrachloride is accompanied by depression, reduced appetite, weak response to external stimuli. It has been shown a reduction of erythrocytes and hemoglobin in the blood of experimental animals. Eosinophilia and neutrophilia also was observed in these rats. A decrease of functional state of liver is by inhibition of protein synthesis and detoxification functions and significant increased of activity of transaminases and alkaline phosphatase. The use of supplements for medicinal purposes«Sylimask» helped restore the functional state of the experimental rats. On the 30 day experiment, the animals found in the blood increase the number of erythrocytes and hemoglobin. The presence in the composition of dietary supplements milled fruits of milk thistle, bee pollen and ascorbic acid provided an effective anti–inflammatory, antioxidant and hepatoprotective action on experimental hepatitis. Serum of rats by using biologically active supplements significantly increased serum total protein, including albumin, decreased activity of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase. The increase in blood catalase activity and inhibition of lipid peroxidation, as evidenced by a decrease in blood secondary and end products of oxidation by exposure «Sylimasku» is the result of activation of the drug enzymatic antioxidant system level. The use of for cure a preparation of comparison «Hepaton», which also contains in its composition the fruits milk thistle is a positive effect on chronic hepatitis B in the experimental rats. However, the impact of digital measurements was a less pronounced and the period of a full restoration of the functional state of animals longer. 

scholarly journals Positive Effect of Cannabis sativa L. Herb Extracts on Skin Cells and Assessment of Cannabinoid-Based Hydrogels Properties

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 802
Author(s):  
Martyna Zagórska-Dziok ◽  
Tomasz Bujak ◽  
Aleksandra Ziemlewska ◽  
Zofia Nizioł-Łukaszewska
Keyword(s):  
Cannabinoid Receptors ◽  
Cannabis Sativa ◽  
Transepidermal Water Loss ◽  
Neutral Red ◽  
Biologically Active ◽  
Skin Hydration ◽  
Skin Cells ◽  
The Impact ◽  
Positive Effect ◽  
Herb Extracts

The skin is an organ that is constantly exposed to many external factors that can affect its structure and function. Due to the presence of different cannabinoid receptors on many types of skin cells, cannabinoids can interact directly with them. Therefore, as part of this work, the impact of two types of Cannabis sativa L. herb extracts on keratinocytes and fibroblasts was assessed. The content of biologically active compounds such as phenols, flavonoids, chlorophylls and cannabinoids was evaluated. The antioxidant capacity of prepared extracts using the DPPH radical, H2DCFDA probe and measurement of superoxide dismutase activity was also assessed. The cytotoxicity of hemp extracts was determined using the Alamar Blue, Neutral Red and LDH assays. The ability of the extracts to inhibit the activity of matrix metalloproteinases, collagenase and elastase, was assessed. Preparations of model hydrogels were also prepared and their effect on transepidermal water loss and skin hydration was measured. The obtained results indicate that hemp extracts can be a valuable source of biologically active substances that reduce oxidative stress, inhibit skin aging processes and positively affect the viability of skin cells. The analysis also showed that hydrogels based on cannabis extracts have a positive effect on skin hydration.

scholarly journals Growth, development and yield of beet varieties under the action of biological products

2021 ◽  
Vol 1 (98) ◽  
pp. 92-104
Author(s):  
О. I. Ulyanich ◽  
◽  
S. A. Vdovenko ◽  
V. V. Yatsenko ◽  
M. M. Chmil
Keyword(s):  
Growth And Development ◽  
Climatic Conditions ◽  
Biologically Active ◽  
Forest Steppe ◽  
Marketable Yield ◽  
Biological Products ◽  
Blade Area ◽  
Cultivation Technology ◽  
The Impact ◽  
Positive Effect

The search for new conditions for growing vegetables in organic crops in order to obtain safe products and in connection with changes in climatic conditions requires an immediate solution. The article considers and proves that the use of biological products affects the formation of highly productive crops and promotes the production of products with a high content of biologically active substances. Studies have shown a positive effect of biological products on the growth and development and yield of beetroot varieties Delicatessen and Red Ball. Studies have been conducted to study the technological aspects of growing vegetables, in particular with the use of biological products, taking into account the environmental impact of both growth processes and quantitative and qualitative indicators. Features of various biological products and their efficiency are analyzed. A comparative analysis of the use of biologicals, which allowed to comprehensively assess the impact of elements of cultivation technology on phenological, biometric, indicators, yield and quality of table beet products, development and improvement of elements of technology for their cultivation in the forest-steppe of Ukraine. This involves the use of highly productive varieties, the use of various effective biological products, is relevant for the spread and cultivation of table beets in the forest-steppe of Ukraine. Phenological observations of canteen beet plants showed that they developed differently and reacted differently in the phases of growth and development, depending on the introduced biological products. The technical ripeness phase began on days 121–129 and was longer than in the control. With the introduction of Solutin and Chlorella – 128–129 days, and in short - with the introduction of biological products Helprost vegetable, Helprost vegetable + Phytohelp, Solutin + Phytohelp – 121–125 days. It was proved that table beet plants differed in height, number of leaves, leaf blade area and their total area per hectare, which compared to the control were from the use of a tank mixture of biological products Helprost vegetable + Phytohelp – 28.3–28.7 thousand m2/ha, which is significantly higher than the control by 13.6–14.8 thousand m2/ha. The area of leaves was slightly lower as a result of the use of other drugs and mixtures – 21.8–22.6 thousand m2/ha. The use of a mixture of drugs Helprost vegetable + Phytohelp contributed to an increase in the mass of the root of table beets by 255–350 g, which is significantly higher than the control by 9–10 g. A positive effect on the yield of beetroot was shown by the vegetable Helprost preparation, as well as a mixture of vegetable Helprost + Phytohelp preparations, the use of which provided a yield of 52.4–63.8 t/ha. The use of a mixture of biological products Solutin + Phytohelp improves the appearance of the plant, increases resistance to harmful microorganisms, and the marketable yield increases to 26.0 t/ha and significantly exceeds the control by 3.2 t/ha.

Influence of DAFS-25+polizon composition on blood and functional state of liver of steers at fattening

2020 ◽  
pp. 15-18
Author(s):  
Inna R. Kilmetova ◽  
◽  
Igor A. Rodin ◽  
Nazira I. Khayrullina ◽  
Nikolay G. Fenchenko ◽  
...  
Keyword(s):  
Functional State ◽  
White Blood Cells ◽  
Live Weight ◽  
The Body ◽  
Farm Animals ◽  
Control Group ◽  
Standard Diet ◽  
The Impact ◽  
Experimental Group ◽  
Stimulation Of

Summary. The disbalanced feeding and the uneven distribution of micro- and macroelements in the environment leads to a trace element, in particular hypomelanosis. To accelerate the growth and preservation of young farm animals include in the diet of various biological additives and drugs, which include selenium. For stimulation of weight gain in the livestock industry, as well as for the prevention and treatment of pathological processes in addition to micro - and macrouse amino acids, primarily methionine. The aim of this work was to study the influence of composition of DAFS-25+Polizon on morpho-biochemical parameters of blood and functional state of the liver in fattening bulls of black-motley breed in the conditions of the Republic of Bashkortostan. Experiments using were conducted on bull-calves of black-motley breed of the properties in the properties age from 6 to 15 months. The first experimental group during the experiment was additionally given the composition of DAFS-25+Polizon at a dose of 2 mg/kg, the animals of the control group received a standard diet. To assess the impact of the composition DAFS-25+Polizon on metabolism cattle studied morphological and biochemical indicators of blood and conducted histological examination of the liver. It is established that the use of the composition of DAFS-25+Polizon at a dose of 2 mg/kg increases the number of erythrocytes and hemoglobin in the experimental group and reduces the amount of white blood cells. The serum content of total protein, phosphorus and calcium increases in the group of experimental animals. Microscopic examination of the liver revealed no changes in the structure of the organ and hepatocytes in the experimental group, whereas in the control group hemodynamic disorders and dystrophic changes in liver cells were observed. Thus, the use of the composition DAFS-25+Polizon at a dose of 2 mg/kg of live weight in fattening bulls black-and-white breed contributes to the increase of redox processes in the body, stimulation of metabolism, prevent the development of liver disorders of cellular mechanisms of metabolism, optimizes the structure of the liver, which generally provides higher productivity.

Impact of Digitalization on Service Work in Knowledge-Intensive Business Services: An Empirical Study in Tax Consultancies

2019 ◽  
Vol 3 (4) ◽  
pp. 209-222
Author(s):  
Philipp K. Görs ◽  
Henning Hummert ◽  
Anne Traum ◽  
Friedemann W. Nerdinger
Keyword(s):  
Work Engagement ◽  
Service Work ◽  
Psychological Consequences ◽  
Business Services ◽  
Knowledge Intensive Business Services ◽  
Positive Effects ◽  
Knowledge Intensive ◽  
The Impact ◽  
Positive Effect ◽  
Special Case

Digitalization is a megatrend, but there is relatively little knowledge about its consequences for service work in general and specifically in knowledge-intensive business services (KIBS). We studied the impact of digitalization on psychological consequences for employees in tax consultancies as a special case of KIBS. We compare two tax consulting jobs with very different job demands, those of tax consultants (TCs) and assistant tax consultants (ATCs). The results show that the extent of digitalization at the workplace level for ATCs correlates significantly positively with their job satisfaction. For TCs, the same variable correlates positively with their work engagement. These positive effects of digitalization are mediated in the case of ATCs by the impact on important job characteristics. In the case of TCs, which already have very good working conditions, the impact is mediated by the positive effect on self-efficacy. Theoretical and practical consequences of these results are discussed.

Experimental Study of the Impact of Alisma plantago-aquatica Secretions on Pathogenic Bacteria

2014 ◽  
Vol 1 (3) ◽  
pp. 3-7
Author(s):  
O. Zhukorskyy ◽  
O. Hulay
Keyword(s):  
Pathogenic Bacteria ◽  
Initial Density ◽  
Biologically Active ◽  
Erysipelothrix Rhusiopathiae ◽  
Natural Focus ◽  
Test Species ◽  
Popula Tions ◽  
And Control ◽  
The Impact

Aim. To estimate the impact of in vivo secretions of water plantain (Alisma plantago-aquatica) on the popula- tions of pathogenic bacteria Erysipelothrix rhusiopathiae. Methods. The plants were isolated from their natural conditions, the roots were washed from the substrate residues and cultivated in laboratory conditions for 10 days to heal the damage. Then the water was changed; seven days later the selected samples were sterilized using fi lters with 0.2 μm pore diameter. The dilution of water plantain root diffusates in the experimental samples was 1:10–1:10,000. The initial density of E. rhusiopathiae bacteria populations was the same for both experimental and control samples. The estimation of the results was conducted 48 hours later. Results. When the dilution of root diffusates was 1:10, the density of erysipelothrixes in the experimental samples was 11.26 times higher than that of the control, on average, the dilution of 1:100 − 6.16 times higher, 1:1000 – 3.22 times higher, 1:10,000 – 1.81 times higher, respectively. Conclusions. The plants of A. plantago-aquatica species are capable of affecting the populations of E. rhusiopathiae pathogenic bacteria via the secretion of biologically active substances into the environment. The consequences of this interaction are positive for the abovementioned bacteria, which is demon- strated by the increase in the density of their populations in the experiment compared to the control. The intensity of the stimulating effect on the populations of E. rhusiopathiae in the root diffusates of A. plantago-aquatica is re- ciprocally dependent on the degree of their dilution. The investigated impact of water plantain on erysipelothrixes should be related to the topical type of biocenotic connections, the formation of which between the test species in the ecosystems might promote maintaining the potential of natural focus of rabies. Keywords: Alisma plantago-aquatica, in vivo secretions, Erysipelothrix rhusiopathiae, population density, topical type of connections.

Comparative study of the impact of two mechanical perforation densities on the behavior of a sandy soil

2012 ◽  
Vol 8 (1) ◽  
pp. 37-48
Author(s):  
S. Chehaibi ◽  
K. Abrougui ◽  
F. Haouala
Keyword(s):  
Soil Water ◽  
Sandy Soil ◽  
Water Infiltration ◽  
Cone Penetration ◽  
Initial State ◽  
Soil Water Infiltration ◽  
Good Improvement ◽  
The Impact ◽  
Positive Effect ◽  
Resistance To Penetration

The effects of mechanical perforation densities by extracting soil cores through an aerator Vertidrain with a working width of 1.6 m and equipped with hollow tines spaced of 65 mm, were studied on a sandy soil of a grassy sward in the Golf Course El Kantaoui in Sousse (Tunisia). The mechanical aeration was performed at two densities: 250 and 350 holes/m2. The cone penetration resistance and soil water infiltration were measured. These parameters were performed at initial state before aeration (E0) and then on the 10th, 20th and 30th day after aeration. These results showed that perforation density of 350 holes/m2 had a positive effect on the soil by reducing its cone resistance to penetration compared to the initial state (Rp = 14.8 daN/cm2). At 5 cm depth the decrease in resistance to penetration was 34% and 43% on the 10th and 20th day after aeration, respectively. However, on the 30th day after aeration the soil resistance to penetration tended to grow and its value compared to the initial state decreased only by 21 and 26%, respectively, at 5 and 15 cm of depth only by 10% and 9% with 250 holes/m2 density. The soil water infiltration made a good improvement after aeration compared to the initial state. This parameter increased from 4.8 cm/h to 8.3, 10.9 and 13.1 cm/h with 250 holes/m2 density and to 10, 12.9 and 14.8 cm/h with 350 holes/m2 density on the 10th, 20th and 30th day following the aeration.

Innovative approaches to the correction of chronotrope status of pregnant and lactating women

2016 ◽  
pp. 37-40
Author(s):  
S.I. Zhuk ◽  
◽  
K.K. Bondarenko ◽  
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Active Form ◽  
Biologically Active ◽  
Lactating Women ◽  
Pathological Conditions ◽  
Prevention And Treatment ◽  
The Impact ◽  
High Bioavailability ◽  
Key Words Mthfr

Most recent studies show the impact of violations in the metabolism of folate and metin period in the pathogenesis of neural tube defects (NTD) of the fetus. Metafolin has a number of advantages, which primarily includes direct intake of substances in biologically active form and the optimum effect, even in the case when the patient homozygote and/or heterozygote genotype 677С T polymorphism in MTHFR. With the aim of prevention and treatment of various pathological conditions related to folate deficiency during pregnancy, it is advisable to apply vitamin-mineral complexes, containing metafolin - active form of folate with high bioavailability. Key words: MTHFR, metafolin, folic acid, pregnancy.

Comparative assessment of morphological mechanisms of maintaining structural liver homeostasis in the dynamics of exposure to coal-rock dust and sodium fluoride on the body

2020 ◽  
pp. 189-194
Author(s):  
M. S. Bugaeva ◽  
O. I. Bondarev ◽  
N. N. Mikhailova ◽  
L. G. Gorokhova
Keyword(s):  
Sodium Fluoride ◽  
Morphological Changes ◽  
The Body ◽  
System Level ◽  
Production Factor ◽  
Coal Rock ◽  
The Impact ◽  
Structural Homeostasis ◽  
Rock Dust

Introduction. The impact on the body of such factors of the production environment as coal-rock dust and fluorine compounds leads to certain shift s in strict indicators of homeostasis at the system level. Maintaining the relative constancy of the internal environment of the body is provided by the functional consistency of all organs and systems, the leading of which is the liver. Organ repair plays a crucial role in restoring the structure of genetic material and maintaining normal cell viability. When this mechanism is damaged, the compensatory capabilities of the organ are disrupted, homeostasis is disrupted at the cellular and organizational levels, and the development of the main pathological processes is noted.The aim of the study is to compare the morphological mechanisms of maintaining structural homeostasis of the liver in the dynamics of the impact on the body of coal-rock dust and sodium fluoride.Materials and methods. Experimental studies were conducted on adult white male laboratory rats. Features of morphological mechanisms for maintaining structural homeostasis of the liver in the dynamics of exposure to coal-rock dust and sodium fluoride were studied on experimental models of pneumoconiosis and fluoride intoxication. For histological examination in experimental animals, liver sampling was performed after 1, 3, 6, 9, 12 weeks of the experiment.Results. The specificity of morphological changes in the liver depending on the harmful production factor was revealed. It is shown that chronic exposure to coal-rock dust and sodium fluoride is characterized by the development of similar morphological changes in the liver and its vessels from the predominance of the initial compensatory-adaptive to pronounced violations of the stromal and parenchymal components. Long-term inhalation of coal-rock dust at 1–3 weeks of seeding triggers adaptive mechanisms in the liver in the form of increased functional activity of cells, formation of double-core hepatocytes, activation of immunocompetent cells and endotheliocytes, ensuring the preservation of the parenchyma and the general morphostructure of the organ until the 12th week of the experiment. Exposure to sodium fluoride leads to early disruption of liver compensatory mechanisms and the development of dystrophic changes in the parenchyma with the formation of necrosis foci as early as the 6th week of the experiment.Conclusions. The study of mechanisms for compensating the liver structure in conditions of long-term exposure to coal-rock dust and sodium fluoride, as well as processes that indicate their failure, and the timing of their occurrence, is of theoretical and practical importance for developing recommendations for the timely prevention and correction of pathological conditions developing in employees of the aluminum and coal industry.The authors declare no conflict of interests.

THEORETICAL STUDY OF THE EFFECT OF GEOMETRICAL PARAMETERS AND LOCATION OF ROTOR IMPACT ELEMENTS OF AN IMPACT-CENTRIFUGAL GRINDER ON SPEED AND ANGLES OF CRUSHED PARTICLES FLIGHT

2020 ◽  
Keyword(s):  
Granulometric Composition ◽  
Theoretical Study ◽  
Process Efficiency ◽  
Geometrical Parameters ◽  
Grinding Process ◽  
Main Work ◽  
Impact Element ◽  
The Impact ◽  
Positive Effect ◽  
Efficiency Indicators

One of efficiency indicators of grain grinders is grain granulometric composition. The basis of mixed fodder is crushed grain, the particles of which must have a leveled granulometric composition for subsequent mixing and obtaining a high-quality feed mixture. In agricultural production, hammer crushers are widely used, in which the destruction of grain occurs due to the impact of a hinged hammer. The main disadvantage of these crushers is that not the entire surface of the hammers is involved in grinding, thus reduces grinding process efficiency. A slightly different principle of material destruction is laid down in the basis of the proposed design of the shock-centrifugal grinder. Main work is performed by flat impact elements located on the rotor, which serve to accelerate crushed particles with subsequent impact of them on the bump elements. An important step in the design of new constructions of shock-centrifugal grinders is to determine size and location of the impact elements on the rotor, without which the grinding process is not possible. In the calculation method presented, the dependencies for determining the velocities and angles of a single particle flight from the surface of a flat impact element for its specified dimensions are proposed. Two variants of an impact element location on the rotor are considered and analyzed: radial and at an angle in the direction of rotor rotation. As a result of research carried out, it is noted that in the case of inclined position of an impact element on the rotor an increase in flight speed and flight angles change in crushed particles, which gives the opportunity to have a positive effect on grinding process.

Effects of use of an eHealth platform e-Vita for COPD patients on disease specific quality of life domains

2020 ◽  
Keyword(s):  
Quality Of Life ◽  
Functional State ◽  
Mental State ◽  
Self Management ◽  
Copd Patients ◽  
Before And After ◽  
Ehealth Intervention ◽  
The Impact ◽  
Disease Specific

Background: Integrated disease management with self-management for Chronic Obstructive Pulmonary Disease (COPD) is effective to improve clinical outcomes. eHealth can improve patients’ involvement to be able to accept and maintain a healthier lifestyle. Eventhough there is mixed evidence of the impact of eHealth on quality of life (QoL) in different settings. Aim: The primary aim of the e-Vita-COPD-study was to investigate the effect of use of eHealth patient platforms on disease specific QoL of COPD patients. Methods: We evaluated the impact of an eHealth platform on disease specific QoL measured with the clinical COPD questionnaire (CCQ), including subscales of symptoms, functional state and mental state. Interrupted time series (ITS) design was used to collect CCQ data at multiple time points. Multilevel linear regression modelling was used to compare trends in CCQ before and after the eHealth intervention. Results: Of 742 invited COPD patients, 244 signed informed consent. For the analyses, we only included patients who actually used the eHealth platform (n = 123). The decrease of CCQ-symptoms was 0,20% before the intervention and 0,27% after the intervention; this difference was statistically significant (P=0.027). The decrease of CCQ-mental was 0,97% before the intervention and after the intervention there was an increase of 0,017%; this difference was statistically significant (P=0,01). No significant difference was found in the slopes of CCQ (P=0,12) and CCQ-function (P=0,11) before and after the intervention. Conclusion: The e-Vita eHealth platform had a potential beneficial impact on the CCQ-symptoms of COPD patients, but not on functional state. The CCQ-mental state remained stable after the intervention, but this was a deterioration compared to the improving situation before the start of the eHealth platform. In conclusion, this study shows that after the introduction of the COPD platform, patients experienced fewer symptoms, but their mental state deteriorated slightly at the same time. Therefore, health care providers should be aware that, although symptoms improve, there might be a slight increase in anxiety and depression after introducing an eHealth intervention to support self-management.

Sign in / Sign up

Export Citation Format

Share Document