scholarly journals Ferum in the content of feed additives, prepared feeds and premixes on the pharmaceutical market in Ukraine

2018 ◽  
Vol 20 (83) ◽  
pp. 290-294
Author(s):  
I.M. Derkach ◽  
S.S. Derkach ◽  
I.O. Sotnichenko
Keyword(s):  
Czech Republic ◽  
Pharmaceutical Products ◽  
Dosage Forms ◽  
Pharmaceutical Product ◽  
Feed Additives ◽  
Pharmaceutical Market ◽  
Feed Additive ◽  
Small Animals ◽  
Physiological Processes ◽  
National Market

The article presents the results of researches of the national market of feed additives, prepared feeds and premixes containing Ferum, registered in Ukraine (by the date 1.03.2018). It has been established that, unlike complexes of iron and dextran in the form of injectable solutions, such pharmaceutical products as feed additives, ready-made fodders and premixes containing Ferum are characterized by a variety of release forms for different species of animals and birds. The number of such products is 55, among them 14 items (26%) are products of production of Ukraine, while this pharmaceutical product for poultry is offered mainly by Polish manufacturers. The market of this group of products for small animals is characterized by a large variety of flavoring properties and forms of release: tablets, powders, granules, flakes, jelly or lime slices, etc. There are only three producers of Ukraine of such pharmaceutical products in the Ukrainian market, while the largest number is offered by companies of Germany and Czech Republic. In addition, the company Vita Traat (Germany) offers vitracraft in the form of pellets as a feed for decorative chinchillas. In the pharmaceutical market of complexes of feed additives, prepared feeds and premixes containing Ferum for various types of animals and poultry. There is a trend that manufacturers, in addition to the specifics of the species, age, physiological processes, and for products for dogs and cats their breed too, take into account the modern needs of the ukrainian consumers, for example, Cargill Poland Sp., Department of Kishkovo, Plant of Premixes of the LNB (Poland) exports to Ukraine 5 types of premixes for broilers. The range of  feed additives, ready forages and premixes containing Ferum for bovine animals is less varied, but besides the dry dosage forms, there is a feed additive for calves in the form of calf id peas (Inform Nutrishin Island, Ltd., Ireland). In addition, iron is a part of the substitute of milk for calves. In the national market, there are also Ferum-containing feed additives for animals of different species, which are available in the form of solutions for oral use.

scholarly journals REGULATORY PERSPECTIVES OF PHARMACEUTICAL PRODUCTS IN GHANA

2018 ◽  
Vol 2 (2) ◽  
pp. 7-15
Author(s):  
Raja Mohan Reddy G. ◽  
M. P. Venkatesh ◽  
Achin J. ◽  
Pramod Kumar T.M.
Keyword(s):  
Regulatory Authority ◽  
Generic Drugs ◽  
Pharmaceutical Products ◽  
Pharmaceutical Product ◽  
Pharmaceutical Market ◽  
Regulatory Requirements ◽  
Drug Products ◽  
Drug Registration ◽  
Good Market ◽  
Gain Access

Drug Registration is a procedure of expertise of pharmaceutical product quality, efficacy and safety by the Regulatory Authority. The emergence of various formats has enabled the manufacturers of the drug to easily gain access into various markets and thus was able to place their products into the market. The choice of Ghana as one of the destinations for the market of the Drug products ensures the manufacturer a good market value. Ghana is considered as one of the growing pharmaceutical market in east Africa. Of late, generic drugs are holding a major stake in the pharmaceutical market and are gaining more and more confidence in the usage. Majority of medicines in the Ghana are generic drugs which are considered as value for the money and affordable. With Ghana Regulatory Authority is the Food and Drugs Board, which takes decision to register the product and issues Registration Certificate. This study mainly focuses on the regulatory environment, registration process involved and the regulatory requirements that are applicable for the generic drug products in Ghana.

scholarly journals Baseline Assessment of Poultry Production, Pharmaceutical Product Use, and Related Challenges on Commercial Poultry Flocks in Kano and Oyo States of Nigeria

2021 ◽  
Vol 8 (12) ◽  
pp. 315
Author(s):  
Isabella C. Endacott ◽  
Erika Galipo ◽  
Abel B. Ekiri ◽  
Ruth Alafiatayo ◽  
Kehinde Adebowale ◽  
...  
Keyword(s):  
Vaccination Schedule ◽  
Pharmaceutical Products ◽  
Pharmaceutical Product ◽  
Feed Additives ◽  
Poultry Production ◽  
Baseline Assessment ◽  
Livestock Sector ◽  
Farm Survey ◽  
Commercial Poultry ◽  
Cost Of Drugs

Poultry production is a major component of the livestock sector in Nigeria and continues to expand rapidly; however, it is still constrained by low productivity. A farm survey was conducted to provide a baseline assessment of poultry production (products generated, farm costs, and revenue), pharmaceutical use, and related challenges faced by farmers on 44 commercial poultry farms in Oyo and Kano states of Nigeria. Live spent layers, eggs, and used beddings were the most frequently sold products for revenue. Antibiotic products were widely used, the most reported were Doxygen, Tylosin, and Conflox. Overall, 40% of farms used feed additives (including toxin binders, minerals, and vitamins) and 12% used coccidiostats. Access to pharmaceutical products was a key challenge and appeared to disproportionally affect farmers in the northern part (Kano) of Nigeria. Other challenges included perceived antibiotic ineffectiveness, high cost of drugs, and long distances to pharmaceutical suppliers. Challenges related to vaccine use were unavailability, distance to the supplier, and health issues interfering with the vaccination schedule. Study findings highlight the need for improved access to veterinary pharmaceuticals, particularly in the northern states. Further investigations into the causes of antibiotic ineffectiveness and strategies for distribution of high-quality, effective pharmaceuticals are also necessary.

scholarly journals Misconception about the Role of a Dose in Pharmacology: Short Review Report on the Biological and Clinical Effects

2019 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Health Care Services ◽  
Short Review ◽  
Chemical Substance ◽  
Pharmaceutical Products ◽  
Pharmaceutical Product ◽  
Pharmaceutical Market ◽  
Clinical Effects ◽  
Toxic Property ◽  
Care Services

Screening of the pharmacological property of test chemical substances through experimental design is still a challenge in drug discovery and development. On the one hand, there is scientific misconception about the role of a dose in experimental toxicology. It is considered to be the fundamental concept of toxicology by which the poison of a chemical substance is made which is far from scientific reality due to the fact that the nature of a chemical substance could not be changed by simply quantification. This scientific misconception about the role of a dose in toxicology leads to the introduction of harmful pharmaceutical products to the pharmaceutical market as health care services which affect public health in different ways. On the other hand, the toxic property of a chemical substance is diverse, has a variety of adverse effects which make drug safety screening very difficult to analyse toxicity in a harmonized procedure. In conclusion, the dose has no role to eliminate the toxicity of a chemical substance but it has the role to limit the magnitude of pharmacological effect which determines lifespan of an organism. Since the toxic property of a chemical substance is diverse, an integrated biological approach is preferable to analyse its toxicity in a harmonized manner to be able to limit the introduction of harmful pharmaceutical product to the pharmaceutical market.

The effects and mechanisms of acids on the health of piglets and weaners – a review

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Piotr Nowak ◽  
Anita Zaworska-Zakrzewska ◽  
Andrzej Frankiewicz ◽  
Małgorzata Kasprowicz-Potocka
Keyword(s):  
Digestive System ◽  
Buffer Capacity ◽  
Growth Parameters ◽  
Feed Additives ◽  
Feed Additive ◽  
Growth Promoters ◽  
Qualitative And Quantitative ◽  
Inorganic Acids ◽  
Low Activity ◽  
The Eu

AbstractThe rearing of piglets is the most difficult period in the pigs’ production because of their poorly developed digestive system and the low activity of digestive enzymes. Problems in nutrition and stress cause some disorders in the functioning of the digestive system leading to diarrhea and the mortality of piglets. Starting in 2006 in the EU, a total ban on antibiotics in their use as growth promoters was introduced. Since then, new and safe feed additives have been sought in order to replace antibiotics. Organic and inorganic acids as well as their salts were recognized as effective and safe additives. Due to their properties, they can improve feed palatability and digestibility, reduce the buffer capacity of feed, impact the development and functioning of the pig’s digestive system and improve the health and growth parameters. However, the effectiveness of acids is related to their qualitative and quantitative share in the feed additive. In this review, some strategies for using organic acids, their mixtures and also some new multi-component products will be discussed.

ВЛИЯНИЕ КОМПЛЕКСНОЙ МИНЕРАЛЬНО-ВИТАМИННОЙ КОРМОВОЙ ДОБАВКИ НА ГЕМАТОЛОГИЧЕСКИЕ И БИОХИМИЧЕСКИЕ ПОКАЗАТЕЛИ КРОВИ ТЕЛЯТ

2020 ◽  
Author(s):  
M.T. SABITOV ◽  
A.R. FARKHUTDINOVA ◽  
M.G. MALIKOVA ◽  
N.G. FENCHENKO ◽  
N.I. KHAIRULLINA ◽  
...  
Keyword(s):  
Animal Feed ◽  
Food Additives ◽  
Test Group ◽  
Feed Additives ◽  
Feed Additive ◽  
Control Group ◽  
Special Role ◽  
Young Stock ◽  
Black And White ◽  
Calcium Phosphorus

Изучена целесообразность использования в рационах телят черно-пестрой породы комплексной минерально-витаминной кормовой добавки (КМВКД). Установлено пониженное содержание в кормах таких элементов, как кальций, фосфор, магний, сера, марганец, медь, цинк и кобальт. Соотношение питательных и минеральных веществ, степень их доступности для усвоения организмом не обеспечивают их потребность. Использование КМВКД способствовало улучшению всех гематологических показателей. Все испытываемые рецепты, имеющие в своем составе разные варианты макро-, микроэлементов и витаминов положительно влияют на обменные про- цессы в организме животных. У молодняка опытной группы, получавшей подкормку по рецепту 1, количество эритроцитов в сравнении с животными контрольной группы увеличилось на 6,6, гемоглобина на 6,93 соответственно, по рецепту 2 11,05 и 11,39 по рецепту 3 16,75 и 15,27, то есть соотношение макро- и микроэлементов, имеющихся в составе КМВКД и взаимодействие между собой меди, железа и кобальта сыграли особую роль на концентрацию форменных элементов. У молодняка, получавшего подкормку по рецепту 1 количество общего белка в сравнении с животными контрольной группы увеличилось на 1,99, кальция на 16,02, каротина на 10,92 соответственно, по рецепту 2 4,91, 25,96 и 19,12 по рецепту 3 на 3,58, 27,07 и 20,21. Значительное повышение содержания белка, кальция, фосфора и каротина по сравнению с животными контрольной группы объясняется тем, что недостаток их в рационах восполнялся за счет используемой подкормки, в результате их содержание увеличилось в сыворотке, но не выходило за пределы нормативных данных и соответствовало физиологическим нормам.Practicability of using a complex mineral and vitamin feed additive (CMVFA) in the ration of black-and-white calf breed was studied. Decreased content of such elements as calcium, phosphorus, magnesium, sulfur, manganese, copper, zinc, and cobalt was registered. The correlation of nutritive and mineral substances, and the level of their availability for digestion did not provide for their need. CMVFA use facilitated the increase of all hematologic parameters. Tested recipes which had different content of sapropel and zeolite, as well as various types of macronutrients, microelements, and vitamins, positively influenced the digestive processes in animal bodies. Young stock from the test group that was receiving food additives according to recipe No. 1 showed 6.6 increase in the quantity of red blood cells compared to control group animals, and 6.93 increase in hemoglobin quantity the ones who were fed according to recipe No. 2 demonstrated the increase by 11.05 and 11.39 recipe No. 3 showed 16.75 and 15.27 increase, which means that the ratio of macronutrients and microelements present in CMVFA and the mutual interaction of copper, iron, and cobalt played a special role in the concentration of formed elements due to the fact that they are integral elements of blood. Total protein of young stock that was receiving food additives according to recipe No. 1 was 1.99 higher than in test group animals calcium 16.02 higher carotene 10.92 as for recipe No. 2 the values were increased by 4.91, 25.96, and 19.12 recipe No. 3 3.58, 27.07, and 20.21. Substantial increase in the content of protein, calcium, phosphorus, and carotene compared to control group animals can be explained by the fact that their insufficiency in animal feed was replenished due to the use of feed additives, and as a result their content increased in the serum but did not go beyond the norm and corresponded to physiological norms.

scholarly journals Modulation of Chicken Intestinal Immune Gene Expression by Small Cationic Peptides as Feed Additives during the First Week Posthatch

2013 ◽  
Vol 20 (9) ◽  
pp. 1440-1448 ◽  
Author(s):  
Michael H. Kogut ◽  
Kenneth J. Genovese ◽  
Haiqi He ◽  
Christina L. Swaggerty ◽  
Yiwei Jiang
Keyword(s):  
Gene Expression ◽  
Proinflammatory Cytokines ◽  
Proinflammatory Cytokine ◽  
Feed Additives ◽  
Feed Additive ◽  
Cationic Peptides ◽  
Type I ◽  
Immune Gene ◽  
Content Type ◽  
Functional Efficiency

ABSTRACTWe have been investigating modulation strategies tailored around the selective stimulation of the host's immune system as an alternative to direct targeting of microbial pathogens by antibiotics. One such approach is the use of a group of small cationic peptides (BT) produced by a Gram-positive soil bacterium,Brevibacillus texasporus. These peptides have immune modulatory properties that enhance both leukocyte functional efficiency and leukocyte proinflammatory cytokine and chemokine mRNA transcription activitiesin vitro. In addition, when provided as a feed additive for just 4 days posthatch, BT peptides significantly induce a concentration-dependent protection against cecal and extraintestinal colonization bySalmonella entericaserovar Enteritidis. In the present studies, we assessed the effects of feeding BT peptides on transcriptional changes on proinflammatory cytokines, inflammatory chemokines, and Toll-like receptors (TLR) in the ceca of broiler chickens with and withoutS. Enteritidis infection. After feeding a BT peptide-supplemented diet for the first 4 days posthatch, chickens were then challenged withS. Enteritidis, and intestinal gene expression was measured at 1 or 7 days postinfection (p.i.) (5 or 11 days of age). Intestinal expression of innate immune mRNA transcripts was analyzed by quantitative real-time PCR (qRT-PCR). Analysis of relative mRNA expression showed that a BT peptide-supplemented diet did not directly induce the transcription of proinflammatory cytokine, inflammatory chemokine, type I/II interferon (IFN), or TLR mRNA in chicken cecum. However, feeding the BT peptide-supplemented diet primed cecal tissue for increased (P≤ 0.05) transcription of TLR4, TLR15, and TLR21 upon infection withS. Enteritidis on days 1 and 7 p.i. Likewise, feeding the BT peptides primed the cecal tissue for increased transcription of proinflammatory cytokines (interleukin 1β [IL-1β], IL-6, IL-18, type I and II IFNs) and inflammatory chemokine (CxCLi2) in response toS. Enteritidis infection 1 and 7 days p.i. compared to the chickens fed the basal diet. These small cationic peptides may prove useful as alternatives to antibiotics as local immune modulators in neonatal poultry by providing prophylactic protection againstSalmonellainfections.

PSVI-4 Efficacy of Medium Chain Fatty Acids and Fatty Acid-based Feed Additives as a Mitigation Strategy Against Porcine Epidemic Diarrhea Virus and Porcine Reproductive and Respiratory Syndrome Virus

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 216-217
Author(s):  
O L Harrison ◽  
G E Nichols ◽  
J T Gebhardt ◽  
Cassandra K Jones ◽  
Jason C Woodworth ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Porcine Epidemic Diarrhea Virus ◽  
Positive Control ◽  
Feed Additives ◽  
Feed Additive ◽  
Respiratory Syndrome Virus ◽  
Post Inoculation ◽  
Diarrhea Virus ◽  
Medium Chain ◽  
Porcine Epidemic Diarrhea

Abstract Recent research has demonstrated that swine viruses can be transmitted via feed. Chemical feed additives have been suggested for the mitigation of these viruses in complete feed. Therefore, the objective of this study was to evaluate the efficacy of a commercially available formaldehyde-based feed additive, medium chain fatty acid blend (MCFA), and commercially available fatty acid-based products for mitigation of porcine epidemic diarrhea virus (PEDV) and porcine reproductive and respiratory syndrome virus (PRRSV) in a feed matrix. Treatments consisted of: 1) non-treated positive control, 2) 0.33% commercial formaldehyde-based product (Sal Curb; Kemin Industries, Inc.; Des Moines, IA), 3) 0.5% MCFA blend (1:1:1 ratio of C6:0, C8:0, and C10:0, Sigma Aldrich, St. Louis, MO), 4) 0.25%, 5) 0.5%, or 6) 1% of commercial dry mono and diglyceride-based product (Furst Strike; Furst-McNess Company, Freeport, IL), 7) 0.25%, 8) 0.5%, or 9) 1% of commercial dry mono and diglyceride-based product (Furst Protect; Furst-McNess Company, Freeport, IL), 10) 0.25%, 11) 0.5%, or 12) 1% dry mono and diglyceride-based experimental product (Furst-McNess Company, Freeport, IL) with 3 replications/treatment. Treatments were applied to complete swine feed before inoculation with 106 TCID50/g of feed with PEDV or PRRSV. Post inoculation feed was held at ambient temperature for 24 h before being analyzed via qRT-PCR. The analyzed values represent the cycle threshold. Formaldehyde and MCFA decreased (P < 0.05) the detectable RNA of PEDV and PRRSV compared to all other treatments. Furst Strike, Furst Protect, and the experimental product did not significantly impact detectability of PEDV or PRRSV RNA. In conclusion, MCFA and formaldehyde treatments are effective at reducing detection of RNA from PEDV and PRRSV in feed.

scholarly journals Use of Post-Extraction Fir Wood Greenery Residues by the Bioconversion Method with the Production of Feed Additives

Forests ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 272
Author(s):  
Olga O. Mamaeva ◽  
Elena V. Isaeva
Keyword(s):  
Heavy Metals ◽  
Weight Loss ◽  
Maximum Permissible Concentration ◽  
Forest Resources ◽  
Feed Additives ◽  
Feed Additive ◽  
Pleurotus Pulmonarius ◽  
Balsam Poplar ◽  
Fallen Leaves ◽  
Protein Feed

The effectiveness of forest resources depends on the comprehensiveness and rationality of their consumption and processing into finished products. This article discusses the problem of using solid fir wood greenery residues generated during the industrial production of essential oils. Bioconversion is considered to be the most promising use. The objective of this research was to study the chemical composition of bioconversion products of fir wood greenery-based substrates. The РР-3.2 strain of Pleurotus pulmonarius (Fr.) Quél was used as a biodestructor. In the process of bioconversion, the contents of polysaccharides and lignin substances is reduced to 38% and 28%, respectively. Up to 20% of protein accumulates in bioconversion products of fir wood greenery. The amount of nucleic acids is not more than 1.5 g per kg; the contents of heavy metals, such as mercury, cadmium, arsenic, and lead, do not exceed the maximum permissible concentration standards. The substrate weight loss reaches 15%. When fallen leaves and post-extraction poplar bud residues are added to the substrate, the substrate-destroying activity of fungi increases, and the protein content increases by 3%. The digestibility of products as a result of bioconversion increases 1.6–2.8 times depending on the substrate composition. The obtained data support the recommendation of post-fermented substrates based on fir wood greenery and balsam poplar biomass for use as a protein feed additive.

Assortment Analysis And Comparative Characteristics Of The Results Of Registration Of Sedative Drugs In The Republic Of Uzbekistan

2021 ◽  
Vol 03 (07) ◽  
pp. 77-91
Author(s):  
Firuza Alisherovna Umarova ◽  
◽  
Kamal Saidakbarovich Rizaev ◽  
Nemat Kayumovich Olimov ◽  
Zaynab Enverovna Sidametova ◽  
...  
Keyword(s):  
Medicinal Product ◽  
Raw Materials ◽  
Dosage Forms ◽  
Pharmaceutical Market ◽  
Joint Stock Company ◽  
Stock Company ◽  
Dry Extract ◽  
The Republic ◽  
Sedative Drugs

Analysis of the assortment of sedatives registered in the Republic of Uzbekistan showed that sedatives are represented on the pharmaceutical market of the country by such dosage forms as drops, solutions, tinctures, syrups, medicinal herbal raw materials, capsules and tablets. Considering that sedatives registered in the form of a substance, with the exception of the dry extract of Leoglycyrfl produced by “Uzkimyofarm”, there are practically no names of S.K. Islambekov in the Joint Stock Company. In this regard, we consider it expedient to create a new sedative medicinal product of herbal origin in the form of a substance and obtain dosage forms based on it.

Amperometric detection of water-soluble antioxidants in chitosan-based feed additives and in sheep blood serum

2020 ◽  
Vol 1 (4) ◽  
pp. 68-74
Author(s):  
A. A. Savina ◽  
◽  
A. A. Volnin ◽  
N. V. Bogolyubova ◽  
O. A. Voronina ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Blood Serum ◽  
Amperometric Detection ◽  
Feed Additives ◽  
Water Soluble ◽  
High Protein ◽  
Feed Additive ◽  
Microbiological Synthesis ◽  
Sheep Blood ◽  
Amperometric Method

The effects of chitosan on various metabolic and digestive processes in the animal body are an important to study because of the production quality for animal nutrition, healthcare, etc. The major known changes in the biochemical parameters of the animal liquids (by chitosan usage as feed additive) are the following: ratio of volatile and fatty acids, content of fat, mineral composition, etc. The aim of this study was to evaluate the total amount of water-soluble antioxidants (TAWSA) of feed additives based on chitosan and high protein concentrate of microbiological synthesis and to assess the effect of these feed additives on TAWSA values of sheep blood serum by amperometric method. Firstly, the antioxidant activity of feed components based on chitosan or/and a high-protein microbiological synthesis concentrate was studied in this work. Second, the experiments are carried out on 6 fistula animals to confirm the results of laboratory studies. Third, the determination of the total antioxidant activity of sheep blood by using chitosan additives (as the feed components) by amperometric method was carried out. A particular difference in antioxidant activity of the control and experimental samples of the sheep blood was established for the first time.

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