Meningiomas: An Overview of the Landscape of Copy Number Alterations in Samples from an Admixed Population

Meningiomas are considered the most common intracranial tumors, affecting mainly women. Studies in mixed populations can be of great importance to clarify issues related to the genetic diversity of tumors and their development. Considering that data obtained from analyses of the profile of copy number alterations (CNA) have been a useful diagnostic indicator for many types of tumors and that meningiomas show a complex pattern of gains and losses in the number of copies, our objective was to analyze the CNA profile in 33 samples of meningiomas of different histological grades (WHO Grade I-III) from patients in a city located in the Amazon region of Brazil, using aCGH. We found that the female to male ratio was 3 : 1. The aCGH analysis revealed a total of 2304 CNA, with an average of 69.8 ± 57.4 per case, of which 1197 were gains (52%), 926 were losses (40.2%), 105 were amplifications (4. 5%), and 76 were deletions (3.3%). A significant relationship was observed between the type of CNA and the degree of the tumor (chi-square test: χ2 = 65,844; p<0.0001; contingency coefficient: C = 0.1772; p<0.0001). Evaluating the recurrent changes in at least 50% of the samples, we observe as the most frequent losses of the segments 22q13.1-q13.2 (82%), 1p35.3 (76%), and 14q13.1-q13.2 (67%), involving all histopathological grades. The analysis of these regions showed the inclusion of genes with functions such as regulation, maintenance of cell survival, reorganization of the cytoskeleton, cell signaling, and DNA repair, among others. However, overall, the profiles observed in meningiomas of this admixed population were very similar to the ones observed in Caucasian groups. An interesting finding was a recurrent gain of 8p22 observed only in grade I meningiomas, a region which includes DLC1, a suppressor candidate gene probably implicated in the developments or progression of meningiomas, usually found deleted, when related to CNAs.

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AGRICULTURAL RISK AND ITS PERCEPTION AMONG PROTEIN PLANT FARMERS

Annals of the Polish Association of Agricultural and Agribusiness Economists ◽

10.5604/01.3001.0013.2859 ◽

2019 ◽

Vol XXI (3) ◽

pp. 459-469

Author(s):

Magdalena Śmiglak-Krajewska

Keyword(s):

Market Risk ◽

Descriptive Statistics ◽

Risk And Uncertainty ◽

Agricultural Risk ◽

Chi Square ◽

Production Risk ◽

Average Rating ◽

Contingency Coefficient ◽

Chi Square Test ◽

Perceive Risk

As farmers are exposed to risk and uncertainty, they are unable to make optimal choices. The main purpose of this paper was to present how farmers perceive risk in agriculture.To meet the objective defined above, this paper relied on the results of a 2018 survey conducted with a sample of 137 legume farms across the country. The information was analyzed and described with the use of descriptive statistics methods. Also, the correlation between selected characteristics was assessed with the Pearson’s contingency coefficient (C) based on the chi-square test of independence. Most interviewees (71%) perceive the effects of risk as the possible emergence of losses or profits, while 29% associate risks with losses only. None of the interviewees declared the perception of risks purely as an opportunity to reap benefits. The respondents believe that agricultural businesses should be most wary of production risk (an average rating of 11.6) and market risk (8.1 to 9.0).

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Quality Label as the Guarantee of Top Quality Agricultural and Food Products Produced in Slovak Republic – a Case Study of Slovak Food Market

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis ◽

10.11118/actaun201664061937 ◽

2016 ◽

Vol 64 (6) ◽

pp. 1937-1950 ◽

Cited By ~ 2

Author(s):

Ingrida Košičiarová ◽

Ľudmila Nagyová ◽

Mária Holienčinová ◽

Jana Rybanská

Keyword(s):

Slovak Republic ◽

Food Products ◽

Quality Level ◽

Chi Square ◽

Exact Test ◽

Quality Label ◽

National Quality ◽

Contingency Coefficient ◽

Chi Square Test ◽

High Level

The aim of the present paper was to determine the Slovak consumer’s opinion about the purchase and quality level of agricultural and food products produced in the Slovak Republic, as well as to determine their knowledge and preference of the National Quality Label “Značka kvality SK”. As research methods, there have been used the methods of survey and structured questionnaire consisting of 22 questions. The total number of respondents was 2.808 randomly selected respondents from all over the Slovak Republic. For a deeper analysis of the obtained results, there have been set out nine hypothesis, which have been tested with the use of Pearson’s chi-square test, Fisher’s exact test, Mann-Whitney U-Test and Cramer’s contingency coefficient. The results of the present paper show, that the knowledge and preference of higher quality food is between Slovak consumers on a pretty high level – more than 44 % respondents think that they buy higher quality products, more than 49 % of respondents think that the agricultural and food products produced in Slovak Republic are rather higher and higher quality, more than 58 % of respondents know the Quality Label “Značka kvality SK”, over 56 % of respondents could describe its logo, more than 60 % of them could spontaneously name five brands, respectively products labelled with this Quality Label and almost 50 % of respondents buy also the ecological products.

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HUBUNGAN KEBERADAAN JENTIK NYAMUK DAN PERILAKU PEMBERANTASAN SARANG NYAMUK DEMAM BERDARAH DENGUE (PSN-DBD) MASYARAKAT DI DAERAH ENDEMIS DAN NON ENDEMIS KECAMATAN NANGGULAN KABUPATEN KULON PROGO

The Indonesian Journal of Public Health ◽

10.20473/ijph.v11i1.2016.28-39 ◽

2017 ◽

Vol 11 (1) ◽

pp. 28

Author(s):

Arif Budiman

Keyword(s):

Influential Factor ◽

Chi Square ◽

Cross Sectional ◽

The Public ◽

Health Officer ◽

Contingency Coefficient ◽

Chi Square Test ◽

Mosquito Breeding ◽

Cross Sectional Design ◽

Planting Season

Dengue fever occurrences are still problematic in Nanggulan district, Kulon Progo regency, which is in each year, the number of cases varies in each village. This research used ‘cross sectional’ design which samples of this research were taken from all the houses in Wijimulyo village as endemic village, and Banyuroto village as non-endemic village. The number of samples used in this research of 94 respondents. The instrument that used in obtaining data were questionnaires and observation check list. The result of Chi Square test in endemic village with influential factor dengue mosquito brending eradication was respondent attitude (p = 0,009) Contingency coefficient (p = 0,391), corelation is adequate, and action (p = 0,009) contingency coeficcient (p = 0,391) corelation is adequate . The result of Chi Square test in non endemic village with influential factor mosquito brending eradication was action (p = 0,011) Contingency coefficient (p = 0,422) corelation is adequate and action (p = 0,040) Contingency coefficient (p = 0,365) corealtion is adeqaute and it is found the fact that it’s better in non endemic village than in endemic village. Variable which influenced respondent attitude and existance of wiggler were not draining the tub over a week, used bucket, used can, used tire, not covering the tub, having fishless fond, so that the public health departement through Puskesmas suggest to conduct counseling of dengue mosquito breeding eridication, fond village monitoring by village officer and health officer to be drained in harvest season until planting season, changing permanent tub with impermanent one or big bucket in order to be easy to be cleaned.Keywords:Dengue Fever, Mosquito Breedin

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PREFERENCES OF CENTRAL EUROPEAN CONSUMERS IN CIRCULAR ECONOMY

Ekonomicko-manazerske spektrum ◽

10.26552/ems.2021.2.99-110 ◽

2021 ◽

Vol 15 (2) ◽

pp. 99-110

Author(s):

Judit Olah ◽

Adriana Tiron Tudor ◽

Vadim Pashkus ◽

Genady Alpatov

Keyword(s):

Generation X ◽

Circular Economy ◽

Sustainable Consumption ◽

Value Added ◽

Fashion Industry ◽

Chi Square ◽

Central European ◽

Generation Z ◽

Contingency Coefficient ◽

Chi Square Test

Research background: Consumers’ interest in environmental responsibility, sustainable consumption, and the circular economy is significantly increasing in all aspects of their lives. Clothing and fashion are clearly among these aspects. The fashion industry is one of the most resource-intensive and environmentally polluting industries. Circularity has been offered as a solution to this issue; however, the change must be in the attitudes of all concerned (Musova et al., 2021b). Businesses must react to this requirement for sustainable fashion, which is the reason that new circular concepts have been raised. Different generations prefer different models of circularity. Purpose of the article: The purpose of the current study is to detect the existence of dependency between generation and the fashion industry’s circular models, and to identify consumers’ specific preferences. Methods: The original consumer survey was undertaken by the authors in 2021, and involved 513 Slovak and 974 Czech consumers, who responded on their preferences in the circular economy. Pearson’s chi-square test of independence was used to confirm the dependence between consumers’ generation and the circular concept. The significant medium dependence of the nominal variables was confirmed by Pearson’s contingency coefficient, C, and Cramer's V. The relationships between the generation categories of Central European consumers and the categories of the new circular models in the fashion industry were established through correspondence analysis. Findings & Value added: The findings of the study suggest that Baby boomers single out capsule wardrobes, Generation X prefers patchwork and slow fashion, while Millennials prioritise GOTS and SWAP. Finally, Generation Z favours leasing jeans, upcycling, and renting clothes.

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Recurrent DNA copy number alterations in intestinal-type sinonasal adenocarcinoma

Rhinology Journal ◽

10.4193/rhino15.382 ◽

2016 ◽

Vol 54 (3) ◽

pp. 278-286

Author(s):

J. Perez-Escuredo ◽

A. Lopez-Hernandez ◽

M. Costales ◽

F. Lopez ◽

S.P. Ares ◽

...

Keyword(s):

Clinical Outcome ◽

Copy Number ◽

Genetic Alterations ◽

Intestinal Type ◽

Dust Exposure ◽

Copy Number Alterations ◽

A Genome ◽

Sinonasal Adenocarcinoma ◽

Gains And Losses ◽

Microarray Cgh

Background: Intestinal-type sinonasal adenocarcinoma (ITAC) is a rare tumour related to occupational wood dust exposure. Few studies have described recurrent genetic changes on a genome-wide scale. The aim of this study was to obtain a high resolution map of recurrent genetic alterations in ITAC. Material and methods: Copy number alterations were evaluated by microarray CGH and MLPA in 37 primary tumours. The results were correlated with pathological characteristics and clinical outcome. Results: Microarray CGH identified the following recurrent aberrations, in descending order: gains at 5p15 (22 cases, 60%), 8q24 (21 cases, 57%), 20q13 (20 cases, 54%), 20q11, and 8q21 (19 cases, 51%), 20p13, and 7p11 (16 cases, 43%), and losses at 5q11-qter, 8p12-pter, and 18q12-23 (15 cases, 40%), and 17p13, and 19p13 (13 cases, 35%). MLPA analysis confirmed this global pattern of gains and losses. Chromosomal loss at 4q32-ter and gains at 1q22, 6p22 and 3q29, as well as deletion of TIMP2 and CRK correlated with unfavourable clinical outcome. Conclusion: ITACs have a unique pattern of chromosomal abnormalities. The four different histological subtypes of ITAC appeared genetically similar. Four chromosomal gains and losses and two specific genes showed prognostic value and may be involved in tumour progression.

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High Resolution Screening of Copy-Number Alterations in Chronic Lymphocytic Leukemia Using Affymetrix 250K SNP-Arrays Reveals a Higher Complexity of Genomic Alterations in Patients with Unmutated IGHV Genes

Blood ◽

10.1182/blood.v112.11.3133.3133 ◽

2008 ◽

Vol 112 (11) ◽

pp. 3133-3133

Author(s):

Rebeqa Gunnarsson ◽

Anders Isaksson ◽

Hanna Göransson ◽

Larry Mansouri ◽

Mattias Jansson ◽

...

Keyword(s):

High Resolution ◽

Copy Number ◽

Average Length ◽

Lymphocytic Leukemia ◽

Copy Number Alterations ◽

Snp Arrays ◽

Genetic Complexity ◽

Trisomy 12 ◽

Allelic Deletion ◽

Gains And Losses

Abstract Chronic lymphocytic leukemia (CLL) is a biologically heterogeneous disease where no common genetic aberration so far has been described. Although recurrent genomic aberrations of prognostic significance are well established (e.g. deletions of 11q, 13q, 17p and trisomy 12), less is known about the overall genetic complexity. Recent development of high-resolution single nucleotide polymorphism (SNP)-arrays will allow screening of genetic complexity, which includes detection of smaller copy-number alterations (CNAs) in addition to the known, recurrent aberrations. We here applied the Affymetrix GeneChip® Mapping 250K Nsp arrays and screened peripheral blood samples from 203 newly diagnosed CLL patients (≥70% tumor cells) from a population-based Scandinavian cohort. The male:female ratio was 2:1, the majority of patients was in stage A (70%) and the median age at diagnosis 61 years. Sixty percentage of cases displayed mutated IGHV genes whereas 35% showed unmutated IGHV genes. The Nexus copy-number software (Biodiscovery, Inc.) was applied and CNAs were identified in all CLL samples investigated, where deletions were more commonly detected than gains (in average, 3.5 vs. 2.2 per sample, respectively). The average length of deletions was 3.5 Mb while gains had an average length of 9.5 Mb (3.6 Mb when excluding trisomy 12). More than 50% of deletions and gains had a size ranging between 0.1–1 Mb, whereas 22% of CNAs were less than 0.1 Mb and 25% larger than 1 Mb. When investigating known, recurrent alterations, 105 samples (52%) carried del(13)(q14); 82 samples displayed a mono-allelic deletion, 15 samples a bi-allelic deletion and 8 samples carried 2 mono-allelic deletions of different sizes. The minimal overlapping region was 0.44 Mb and most of the 13q14 deletions covered the genomic region of miR-15, miR-16 and/or DLEU7. Twenty-one samples (10%) showed trisomy 12 and del(11q) was detected in 27 samples (13%), all covering the ATM gene. del(17p) was detected in 7 patients (3.4%) with one patient also carrying several gains and losses of 17q. Moreover, large alterations involving chromosome arms or entire chromosomes were recurrently observed among the samples, for instance, 3 large 8p losses and 4 large 8q gains. Interestingly, 5 samples, which all carried del(11q), displayed a gain covering whole or large parts of the p-arm of chromosome 2, a region which covers MYCN, REL and BCL11A. Furthermore, comparison of samples with different IGHV mutation status (M vs. UM) illustrated a significantly higher frequency of del(11q) (32% of UM vs. 4% of M), trisomy 12 (22% of UM vs. 5% of M) and gain of 2p (12% vs. 0% in M) in samples with unmutated IGHV genes. As expected, patients with mutated IGHV genes showed a higher frequency of del(13q) (61% of M vs. 31% of UM). In addition, large aberrations (>1Mb) were more common in UM samples which in average displayed 0.57 gains and 1.22 deletions compared to 0.26 gains and 0.67 deletions in M samples. In conclusion, with whole-genome screening using high resolution SNP-arrays, higher complexity was revealed in CLL, including a higher number of gains and losses and a higher frequency of larger aberrations in UM compared to M samples. A novel, recurrent combination of del(11q) and gain of 2p was demonstrated which deserves further investigation.

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Hubungan kecerdasan emosional dengan tingkat stres kerja perawat di ICU dan IGD RSUD kota Kendari

Jurnal Kedokteran Syiah Kuala ◽

10.24815/jks.v19i3.18118 ◽

2019 ◽

Vol 19 (3) ◽

Author(s):

La Rangki ◽

La Ode Alifariki

Keyword(s):

Emotional Intelligence ◽

Work Stress ◽

Chi Square ◽

Cross Sectional ◽

Working Stress ◽

Nursing Services ◽

Contingency Coefficient ◽

Chi Square Test ◽

The Relationship

Abstrak: Perawat yang bekerja di ICU dan IGD sangat rentan terhadap stres. Stres kerja yang dialami perawat akan sangat mempengaruhi kualitas pelayanan keperawatan yang diberikan kepada pasien. Tujuan penelitian ini adalah untuk mengetahui hubungan antara kecerdasan emosional dengan stres kerja perawat di ICU dan IGD RSUD Kota Kendari. Penelitian ini merupakan penelitian deskriptif analitik korelasi dengan menggunakan pendekatan kuantitatif dengan metode cross sectional. Data tingkat kecerdasan emosional dan tingkat stres kerja responden dikumpulkan dengan kuesioner. Subyek penelitian berjumlah 18 orang perawat ICU dan IGD dengan kriteria : tidak sedang dalam masa cuti atau mendapat tugas belajar, bersedia menjadi responden, dan bukan kepala ruang. Penelitian dilakukan pada bulan Februari 2018. Kecerdasan emosional perawat berada pada tingkatan sedang yakni 55,56% responden dan rata-rata tingkat stres kerja perawat dalam kategori sedang yakni 55,56% responden. Hasil uji statistik dengan menggunakan uji Chi Square pada tingkat kepercayaan 95% (=0.05), diperoleh nilai Contingency Coefficient 0.486 dan nilai hit= 5.580 = 3.841 yang berarti H0 ditolak sehingga disimpulkan bahwa ada hubungan antara kecerdasan emosional dengan tingkat stres kerja perawat di instalasi rawat darurat RSUD Kota Kendari.Kata Kunci: Kecerdasan Emosional, Stres Kerja, Perawat, ICU dan IGD Abstract: Nurses working in ICU and IGD are very susceptible to stress. Work stress experienced by nurses will greatly affect the quality of nursing services provided to patients. The purpose of this study was to determine the relationship between emotional intelligence with work stress nurses in ICU and IGD Kendari Regional Hospital. This research is a descriptive analytic correlation research using a quantitative approach with cross sectional method. Data of emotional intelligence level and work stress level of respondent were collected by questionnaire. The subjects of the study were 18 nurses ICU and IGD with criteria: not in the time of leave or get the task of study, willing to be respondent, and not head of space. The study was conducted in February 2018. Emotional intelligence of nurses was at the moderate level of 55.56% of respondents and the average level of nurses' work stress in the medium category ie 55.56% of respondents. The result of statistical test using Chi Square test at 95% confidence level (= 0.05), obtained the value of Contingency Coefficient 0.486 and the value 2 hit = 5.580 〖x〗 ^ 2 = 3.841 which means H0 is rejected so it is concluded that there is a relationship between intelligence emotional with the level of nurses work stress at the emergency hospital installation RSUD Kendari.Keywords: Emotional Intelligence, Working Stress, Nurse, ICU and IGD

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Kontribusi Pengetahuan Kader Terhadap Kinerja Kader Posyandu di Puskesmas Matandahi Konawe Utara

Jurnal Penelitian dan Pengembangan Pelayanan Kesehatan ◽

10.22435/jpppk.v2i1.37 ◽

2018 ◽

pp. 17-22

Author(s):

Lukwan Lukwan

Keyword(s):

Cross Sectional Study ◽

Drop Out ◽

Test Results ◽

Sectional Study ◽

Chi Square ◽

Cross Sectional ◽

Contingency Coefficient ◽

Chi Square Test ◽

Analytical Research ◽

Independent Variable

Abstrak Salah satu permasalahan Indonesia secara nasional yang berkaitan dengan kader adalah tingginya angka drop out kader.Tiap Posyandu hanya memiliki 2 orang kader yang aktif. Tujuan penelitian ini adalah untuk mengetahui kontribusi pengetahuan terhadap kinerja kader Posyandu. Jenis penelitian yang digunakan adalah penelitian analitik dengan desain Cross Sectional Study dimana pengukuran variabel terikat dan variabel bebas dilakukan pada waktu dan tempat secara bersamaan. Data diolah dengan menggunakan uji statistik SPSS dengan teknik analisis data menggunakan uji Chi square dan uji phi. Hasil uji Chi square diperoleh X2 hit (4,375) dan uji koefisien kontingensi C = (0,474) dengan tingkat kepercayaan 95% (α = 0,05). Nilai X2 hit (4,375) > X2 (3,841), maka Ho ditolak dan Ha diterima. Kesimpulannya adalah ada hubungan yang cukup antara pengetahuan dengan Kinerja kader Posyandu di wilayah kerja Puskesmas Matandahi Kabupaten Konawe Utara. Kata kunci: Pengetahuan, Kinerja Kader Posyandu Abstract Nationally, one of Indonesia’s problems related to the cadres is the high number of drop out cadres. Each Posyandu only has 2 active cadres. The purpose of this study is to know the contribution of knowledge to the performance of Posyandu cadres. The type of research used is analytical research with Cross Sectional Study design where the measurement of dependent variable and independent variable is done at the same time and place. Data were processed by using statistical test of spss with technique of data analysis using chi square test and phi test. Chi square test results obtained X2 hit (4.375) and contingency coefficient test C = (0.474) with 95% confidence level (α = 0.05). X2 hit value (4.375) > X2 (3.841), then Ho is rejected and Ha accepted. The conclusion is that there is a sufficient relationship between knowledge with the performance of Posyandu cadres in the working area of the Puskesmas Matandahi Kabupaten Konawe Utara. Keywords: Knowledge, Performance of Posyandu Cadre’s

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HUBUNGAN PREEKLAMSIA DENGAN KEJADIAN BERAT BADAN LAHIR RENDAH

PREPOTIF : Jurnal Kesehatan Masyarakat ◽

10.31004/prepotif.v5i1.1411 ◽

2021 ◽

Vol 5 (1) ◽

pp. 139-145

Author(s):

Mika Oktarina ◽

Tria Nopi Herdiani ◽

Ida Rahmawati ◽

Ratna Susanti

Keyword(s):

Birth Weight ◽

Health Workers ◽

Secondary Data ◽

Sampling Technique ◽

Bivariate Analysis ◽

Chi Square ◽

Cross Sectional ◽

Normal Birth ◽

Contingency Coefficient ◽

Chi Square Test

Preeclampsia and eclampsia is a complication in the labor process whose incidence is always high. The purpose of this study was to study the relationship between Birth Weight and the incidence of preeclampsia in RSUD dr. M. Yunus, Bengkulu city in 2017. The type of research used in this study is Survey Analytic using the Cross Sectional method. The population in this study was overall in the hospital of Dr. M. Yunus City of Bengkulu in January to December in 2017 which is 362 babies. The sampling technique in this study was 78 proportional sampling. The data used is secondary data obtained from the patient register at Dr. M Yunus Hospital in Bengkulu. Data were analyzed using univariate and bivariate analysis with Chi-Square test (2) and Contingency Coefficient (C) test. The results obtained: Of the 78 newborns sampled there were 60 infants (76.9%) normal birth weight, 55 people (70.5%) did not experience preeclampsia, there was a significant relationship between preeclampsia and low infant weight in RSUD dr. M. Yunus Bengkulu in the tight category. It is expected that health workers can maintain and improve the quality of their abilities and skills to deal with babies with low birth weight born by preeclampsia patients or other patients.

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Comparative Analysis of Private Labels—Private Labels from the Point of View of a Millennial Customer in Slovakia, Czech Republic and Hungary

Sustainability ◽

10.3390/su12239822 ◽

2020 ◽

Vol 12 (23) ◽

pp. 9822

Author(s):

Ingrida Košičiarová ◽

Zdenka Kádeková ◽

Milan Džupina ◽

Ľubica Kubicová ◽

Marek Dvořák

Keyword(s):

Czech Republic ◽

Research Method ◽

Point Of View ◽

Private Labels ◽

Chi Square ◽

Main Research ◽

Friedman's Test ◽

Contingency Coefficient ◽

Chi Square Test ◽

Phi Coefficient

The present paper is focused on the issues of private labels, their establishment, perception and preference by selected groups of respondents, namely consumers under the age of 25 and also inhabitants of selected V4 countries (Slovakia, Hungary and Czech Republic). An anonymous questionnaire survey was chosen as the main research method. A total of 3038 respondents aged under 25 participated—1064 respondents were from Slovakia, 973 from Hungary and 1001 from Czech Republic. This research method was subsequently supplemented with selected statistical methods evaluated in the XL Stat statistical program, SAS Enterprise Guide 7.1 and SAS 9.4, where hypotheses were examined by Pearson’s Chi-Square Test, Mantel–Haenszel Chi-square test, Cramer’s V contingency coefficient, Pearson’s correlation coefficient, Friedman’s test, Kruskal–Wallis test, Correspondence analysis and Phi Coefficient. The results of the survey can be perceived more than positively as most of the respondents declared that they knew the concept of private labels; more than 80% of respondents buy them either regularly or sporadically; just over 32% of respondents explicitly prefer them in their purchases and in terms of the perception of the quality, almost 75% of respondents think the quality of private label products is comparable to that of traditional brands.

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